Vancomycin in the Target Site Treatment of Intracranial Infection : a New Strategy for PK/PD Treatment
Vancomycin in the Target Site Treatment of Intracranial Infection : a New Strategy for PK/PD Treatment
Vancomycin, a novel intravenously administered antibiotic, currently plays a key role in the management of complicated multi-organism infections. However,current LC-MS/MS methods briefly describe parameters and the only reported internal standard was sometimes difficult to obtain. In our study,an updated LC-MS/MS method for the quantitative analysis of vancomycin in human serum was developed.
Inclusion Criteria:
In ICU; ventricle drainage was carried out; renal function is normal, namely creatinine clearance rate is >60ml/min;
Exclusion Criteria:
women in pregnancy or lactation;in patients with renal insufficiency, the creatinine clearance rate (Clcr) is less than 60ml/min.