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Vancomycin, a novel intravenously administered antibiotic, currently plays a key role in the management of complicated multi-organism infections. However,current LC-MS/MS methods briefly describe parameters and the only reported internal standard was sometimes difficult to obtain. In our study,an updated LC-MS/MS method for the quantitative analysis of vancomycin in human serum was developed.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Vancomycin 1g q12h | Experimental |
| |
| Vancomycin 1g q8h | Experimental |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Vancomycin | Drug | Vancomycin, a novel intravenously administered glycylcycline antibiotic, currently plays a key role in the management of complicated multi-organism infections. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Vancomycin concentration change in serum and cerebrospinal fluid | Quantitative analysis of vancomycin in serum and cerebrospinal fluid after treatment by an updated LC-MS/MS method. | 0.5h, 1h, 1.5h, 3h, 5h, 7h, 9h, and 12h after treatment |
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Inclusion Criteria:
In ICU; ventricle drainage was carried out; renal function is normal, namely creatinine clearance rate is >60ml/min;
Exclusion Criteria:
women in pregnancy or lactation;in patients with renal insufficiency, the creatinine clearance rate (Clcr) is less than 60ml/min.
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| Name | Affiliation | Role |
|---|---|---|
| Yanyan Jia, Dr. | The First Affiliated Hospital, the Fourth Military Medical University | Study Director |
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| ID | Term |
|---|---|
| D014640 | Vancomycin |
| ID | Term |
|---|---|
| D006020 | Glycopeptides |
| D006001 | Glycoconjugates |
| D002241 | Carbohydrates |
| D010455 | Peptides |
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| D000602 |
| Amino Acids, Peptides, and Proteins |