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The goal of tish clinical research study is to identify that loading of vancomycin can facilitate rapid attainment of target trough serum vancomycin concentration.
The Study drug
Study design : Randomized controlled trials
Study Drug Administration
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Vancomcyin, maintain dose | No Intervention | This arm is received only maintain dose of vancomycin (15mg/kg twice a day or 1g twice a day). | |
| Vancomycin loading | Experimental | This group is received loading dose 30mg/kg. Subsequent doses of vancomycin are considered standard of care. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Vancomycin HCL | Drug | Loading dose of 30mg/kg via central or peripheral intravenous infusion during 2 or 3 hours. Maintenance dose of vancomycin is 15mg/kg twice a day or 1g twice a day. |
| Measure | Description | Time Frame |
|---|---|---|
| Time duration for concentration of vancomycin to reach target trough of 15-20 mg/L | Peak level drawn 1 hour after the completion of loading dose. Sequential trough level drawn 30 min before each standard dose for the next 4 doses. |
| Measure | Description | Time Frame |
|---|---|---|
| Adverse event rate in each arm, including nephrotoxicity and rash. | 7 days post-treatment |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Kyong Ran Peck, MD | Samsung Medical Center | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Samsung Medical Center | Seoul | 135-710 | South Korea |
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| ID | Term |
|---|---|
| D007239 | Infections |
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| ID | Term |
|---|---|
| D014640 | Vancomycin |
| ID | Term |
|---|---|
| D006020 | Glycopeptides |
| D006001 | Glycoconjugates |
| D002241 | Carbohydrates |
| D010455 | Peptides |
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| D000602 |
| Amino Acids, Peptides, and Proteins |