Effectiveness of Vancomycin Loading Therapy

Effectiveness of Vancomycin Loading Therapy

The goal of tish clinical research study is to identify that loading of vancomycin can facilitate rapid attainment of target trough serum vancomycin concentration.

The Study drug

• Vancomycin : a glycopeptide antibiotic, is the first line agent in the treatment of methicillin resistant staphylococcus aureus

Study design : Randomized controlled trials

Study Drug Administration

• If your doctor believes you are eligible, and you agree to take part in this study, you will be randomized to two treatment groups.

Inclusion Criteria:

• Admission to Samsung Medical Center MICU and general wards for infectious diseases and hematology division
• Patients with SIRS (systemic inflammatory response syndrome)
• Intravenous vancomycin therapy deemed necessary

Exclusion Criteria:

• Age less than 20 years
• Age more than 75 years
• Current renal insufficiency defined as estimated Glomerular filtration rate < 50mg/min/1.73 m2 by MDRD equation
• History of adverse events to vancomycin 5. Pregnant woman