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| ID | Type | Description | Link |
|---|---|---|---|
| NCI-2018-03684 | Registry Identifier | NCI / CTRP | |
| RG1001766 | Other Identifier | Fred Hutch/University of Washington Cancer Consortium | |
| 8659 | Other Identifier | Fred Hutch/University of Washington Cancer Consortium |
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Conversational agents (CAs) are computer-powered digital coaches designed to form long-term social-emotional connections with users through conversations. We have developed a CA for cigarette smoking cessation. In a pilot randomized trial (N = 415), we will compare the experimental messaging program (n = 155) with the standard of care national government smoking cessation messaging program (n = 157), and then we will compare immediate (n=51) versus delayed (n=51) access to the the experimental messaging program, to assess 12-week usability, receptivity, and preliminary cessation results in adults in western Washington State and nationally across the US who want to quit smoking.
Cigarette smoking is the most preventable cause of cancer in the US, accounting for one-third of all cancer deaths. Within the Fred Hutchinson Center's western Washington State 13-county catchment area, there are enormous disparities in adult cigarette smoking rates. Our recently completed WebQuit website RCT for smoking cessation had low engagement and no personalization to users' needs. Fortunately, a potentially game-changing solution to the problems of engagement and lack of personalization provide a new direction for my research. Advances in machine learning, natural language processing, and cloud computing are making it possible to create and widely disseminate conversational agents (CAs), which are computer-powered digital coaches designed to form long-term social-emotional connections with users through conversations. We have developed a CA for cigarette smoking cessation. In a pilot randomized trial (N = 415), we will compare the experimental messaging program with the standard of care national government smoking cessation messaging program, and then we will compare immediate versus delayed access to the the experimental messaging program. Twelve-week usability, receptivity, and preliminary cessation results will provide critical and timely pilot data.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Experimental | Experimental | This is the experimental arm of the study. This includes receiving immediate access to the novel/experimental smoking cessation messaging program. Therapy description withheld to protect the integrity of the study. |
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| Control | Active Comparator | This is the control arm of the study. This includes receiving receiving immediate access to the standard of care smoking cessation messaging program. Therapy description withheld to protect the integrity of the study. |
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| Delayed Control | Active Comparator | This is the second control arm of the study. This includes receiving the novel/experimental smoking cessation messaging program after completing the 3-month follow-up survey. Therapy description withheld to protect the integrity of the study. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Immediate access to novel messaging program intervention | Behavioral | The experimental arm includes an immediate intervention using a novel messaging program for smoking cessation. |
| Measure | Description | Time Frame |
|---|---|---|
| 30-day point prevalence abstinence | No smoking in the past 30 days, as reported 3 month post treatment. | 3 months post randomization |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Jonathan Bricker, PhD | Fred Hutchinson Cancer Center | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Fred Hutchinson Cancer Research Center | Seattle | Washington | 98109 | United States |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 38913882 | Derived | Bricker JB, Sullivan B, Mull K, Santiago-Torres M, Lavista Ferres JM. Conversational Chatbot for Cigarette Smoking Cessation: Results From the 11-Step User-Centered Design Development Process and Randomized Controlled Trial. JMIR Mhealth Uhealth. 2024 Jul 23;12:e57318. doi: 10.2196/57318. |
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| Immediate access to standard of care messaging program intervention | Behavioral | The immediate control intervention uses a standard of care messaging program for smoking cessation. |
|
| Delayed access to novel novel messaging program intervention | Behavioral | The delayed control intervention uses the novel messaging program for smoking cessation. |
|
| ID | Term |
|---|---|
| D016540 | Smoking Cessation |
| D012907 | Smoking |
| ID | Term |
|---|---|
| D015438 | Health Behavior |
| D001519 | Behavior |
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