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| Name | Class |
|---|---|
| University of Roma La Sapienza | OTHER |
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The principal aim of this study is to analyse L3-SMI (skeletal muscle index) in a cohort of patients with decompensated liver cirrhosis and TIPS (transjugular intrahepatic portosystemic shunt), and compare the prognostic power with TPMT (transverse psoas muscle thickness). Furthermore, the role of myosteatosis, determined in CT by L3-SMI, MRI and ultrasound will be studied.
The principal aim of this study is to analyse L3-SMI (skeletal muscle index) in a cohort of patients with decompensated liver cirrhosis and TIPS (transjugular intrahepatic portosystemic shunt), and compare the prognostic power with TPMT (transverse psoas muscle thickness). Furthermore, the role of myosteatosis, determined in CT by L3-SMI, MRI and ultrasound will be studied.
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| imaging | Diagnostic Test | computed tomography, magnetic resosnance imaging, ultrasound |
| Measure | Description | Time Frame |
|---|---|---|
| Survival time | time of survival | up to 60 months |
| Measure | Description | Time Frame |
|---|---|---|
| Time to clinical acute decompensations | time to occurrence of acute decompensations of liver cirrhosis (readmissions, hepatic encephalopathy, bleeding, ascites, hepatorenal syndrome, infections) | up to 60 months |
| Time to clinical acute-on-chronic liver failure |
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Inclusion Criteria:
Exclusion Criteria:
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Patients with liver cirrhosis of any etiology and CT scan available
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Michael Praktiknjo, MD | Contact | +49228 287 15770 | michael.praktiknjo@ukbonn.de | |
| Johannes Chang, MD | Contact | +49228 287 15770 | johannes.chang@ukbonn.de |
| Name | Affiliation | Role |
|---|---|---|
| Michael Praktiknjo, MD | University Hospital, Bonn | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University Hospital Bonn | Recruiting | Bonn | Germany |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 37586906 | Derived | Praktiknjo M, Zhou T, Krusken M, Jacob T, Sprinkart AM, Nowak S, Kimmann M, Dold L, Chang J, Jansen C, Strassburg CP, Luetkens J, Weismuller TJ. Myosteatosis independently predicts transplant-free survival in patients with primary sclerosing cholangitis. Dig Liver Dis. 2023 Nov;55(11):1543-1547. doi: 10.1016/j.dld.2023.08.037. Epub 2023 Aug 14. | |
| 35492329 |
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| ID | Term |
|---|---|
| D008103 | Liver Cirrhosis |
| D055948 | Sarcopenia |
| D005355 | Fibrosis |
| D065290 | Acute-On-Chronic Liver Failure |
| ID | Term |
|---|---|
| D008107 | Liver Diseases |
| D004066 | Digestive System Diseases |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
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| ID | Term |
|---|---|
| D003952 | Diagnostic Imaging |
| ID | Term |
|---|---|
| D019937 | Diagnostic Techniques and Procedures |
| D003933 | Diagnosis |
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acute-on-chronic liver failure according to EASL-CLIF-C definition (grade 1 (best) to 3 (worst) |
| up to 60 months |
| Development of sarcopenia | Assessment of sarcopenia according to EASL-guideline | up to 60 months |
| University of Frankfurt | Recruiting | Frankfurt | Germany |
|
| Sapienza University of Rome | Recruiting | Roma | Italy |
|
| Faron A, Abu-Omar J, Chang J, Bohling N, Sprinkart AM, Attenberger U, Rockstroh JK, Luu AM, Jansen C, Strassburg CP, Trebicka J, Luetkens J, Praktiknjo M. Combination of Fat-Free Muscle Index and Total Spontaneous Portosystemic Shunt Area Identifies High-Risk Cirrhosis Patients. Front Med (Lausanne). 2022 Apr 12;9:831005. doi: 10.3389/fmed.2022.831005. eCollection 2022. |
| 31644538 | Derived | Queck A, Thomas D, Jansen C, Schreiber Y, Ruschenbaum S, Praktiknjo M, Schwarzkopf KM, Mucke MM, Schierwagen R, Uschner FE, Meyer C, Claria J, Zeuzem S, Geisslinger G, Trebicka J, Lange CM. Pathophysiological role of prostanoids in coagulation of the portal venous system in liver cirrhosis. PLoS One. 2019 Oct 23;14(10):e0222840. doi: 10.1371/journal.pone.0222840. eCollection 2019. |
| 30939488 | Derived | Praktiknjo M, Clees C, Pigliacelli A, Fischer S, Jansen C, Lehmann J, Pohlmann A, Lattanzi B, Krabbe VK, Strassburg CP, Arroyo V, Merli M, Meyer C, Trebicka J. Sarcopenia Is Associated With Development of Acute-on-Chronic Liver Failure in Decompensated Liver Cirrhosis Receiving Transjugular Intrahepatic Portosystemic Shunt. Clin Transl Gastroenterol. 2019 Apr;10(4):e00025. doi: 10.14309/ctg.0000000000000025. |
| D009133 | Muscular Atrophy |
| D020879 | Neuromuscular Manifestations |
| D009461 | Neurologic Manifestations |
| D009422 | Nervous System Diseases |
| D001284 | Atrophy |
| D020763 | Pathological Conditions, Anatomical |
| D012816 | Signs and Symptoms |
| D017114 | Liver Failure, Acute |
| D017093 | Liver Failure |
| D048550 | Hepatic Insufficiency |