Inflammatory Biomarkers of Pediatric Pulmonary Hypertension

Inflammatory Biomarkers of Pediatric Pulmonary Hypertension: a Prospective Cohort Study

To investigate if the inflammatory protein, high mobility group box 1 (HMGB1), along with other inflammatory mediators, is elevated in pediatric patients with congenital heart disease (CHD) and pulmonary hypertension as compared to those with CHD alone, or with healthy controls.

Inclusion Criteria:

-patients of any age with congenital cardiac disease coming for catheterization of the right heart, or both the right and left heart.

Exclusion Criteria:

• active systemic infection
• current active cancer
• active cancer treatment
• prior bone marrow transplant
• prior solid organ transplant