Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
The purpose of this study is to analyse the sensitivity and specificity of circulating endothelial cells to predict irreversible pulmonary arterial hypertension associated with congenital heart disease.
predict to recruit 100 patients with pulmonary arterial hypertension (PAH)associated with CHD，under the commitment of the children's parents，take 3-4ml central venous blood before the corrective surgery，then calculate the number of the circulating endothelial cells by flow cytometer AND detect the expression of micro RNAs to screen out the biomarker，through the 6 months follow-up, separated the reversible and irreversible PAH,then to carry on the statistics.
Not provided
Not provided
Not provided
Not provided
Not provided
| Label | Type | Description | Intervention Names |
|---|---|---|---|
| reversible PAH group | reversible PAH was defined as sPAP decreasing to 40 mmHg after follow-up more than 6 months through echocardiography. | ||
| irreversible PAH group | irreversible PAH was defined as 6 months after surgery through echocardiography ，the sPAP remaining 40 mmHg or up |
Not provided
| Measure | Description | Time Frame |
|---|---|---|
| the number of Circulation endothelial cells and the detective count of microRNAs | the number of Circulation endothelial cells and the detective count of microRNAs in the biomarkers in both groups differd significantly. | 6 months after corrective surgery |
Not provided
Not provided
Inclusion Criteria:
Exclusion Criteria:
Not provided
Not provided
those patients with systolic PAP (sPAP) >65mmHg before surgery were included.
Not provided
| Name | Affiliation | Role |
|---|---|---|
| Zhuoming Xu, Ph D | Shanghai Jiao Tong University School of Medicine | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Shanghai Children's Medical Center | Shanghai | Shanghai Municipality | 200127 | China |
Not provided
| ID | Term |
|---|---|
| D006976 | Hypertension, Pulmonary |
| ID | Term |
|---|---|
| D008171 | Lung Diseases |
| D012140 | Respiratory Tract Diseases |
| D006973 | Hypertension |
| D014652 | Vascular Diseases |
Not provided
Not provided
Not provided
Not provided
Not provided
| D002318 |
| Cardiovascular Diseases |