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| Name | Class |
|---|---|
| Universidad Complutense de Madrid | OTHER |
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Primary progressive aphasia (PPA) is a clinical syndrome characterized by the neurodegeneration of language brain systems. Three main clinical variants are currently recorgnized (nonfluent, semantic, and logopenic PPA). Nowadays, there are no effective treatments for this disorder.
Transcranial Magnetic Stimulation (TMS) is a technique based on the principle of electromagnetic induction of an electric field in the brain. It has been used as a non-invasive therapy in different disorders, such as depression, bipolar disorder, Parkinson's disease, and in the rehabilitation of post-stroke aphasia. Recent studies have shown how repetitive TMS improved language characteristics in Alzheimer's disease, and there are initial data in patients with PPA.
This research project investigates the effect of repetitive TMS in patients with PPA. Investigators will perform a personalized TMS treatment for each patient (brain region, type of stimulation/inhibition, etc.), according to the specific characteristics of each patient and with the final aim to generate a computational model.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Repetitive TMS (estimulation) | Experimental |
| |
| Repetitive TMS (inhibition) | Active Comparator |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Transcranial Magnetic Stimulation | Device | Stimulation or inhibition using TMS will be delivered guided by a neuronavigator system in different brain regions. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Changes in spontaneous speech (main primary endpoint) | Picture and story description task | 2 months (at baseline and at the end of the treatment) |
| Changes in oral naming | Object naming test | 2 months |
| Changes in reading | Story and words reading test | 2 months |
| Changes in repetition | Non-words and sentence repetition task | 2 months (at baseline and at the end of the treatment) |
| Measure | Description | Time Frame |
|---|---|---|
| Changes in brain metabolism | Brain metabolism measured using 18F-FDG-PET | 2 months (at baseline and at the end of the treatment) |
| Changes in clinical impression of change | Patient's clinical impression of change (from 0 to 10) |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Hospital ClÃnico San Carlos. | Madrid | 28040 | Spain |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 34487043 | Derived | Pytel V, Cabrera-Martin MN, Delgado-Alvarez A, Ayala JL, Balugo P, Delgado-Alonso C, Yus M, Carreras MT, Carreras JL, Matias-Guiu J, Matias-Guiu JA. Personalized Repetitive Transcranial Magnetic Stimulation for Primary Progressive Aphasia. J Alzheimers Dis. 2021;84(1):151-167. doi: 10.3233/JAD-210566. |
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| ID | Term |
|---|---|
| D018888 | Aphasia, Primary Progressive |
| ID | Term |
|---|---|
| D003704 | Dementia |
| D001927 | Brain Diseases |
| D002493 | Central Nervous System Diseases |
| D009422 | Nervous System Diseases |
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| ID | Term |
|---|---|
| D050781 | Transcranial Magnetic Stimulation |
| ID | Term |
|---|---|
| D055909 | Magnetic Field Therapy |
| D013812 | Therapeutics |
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| 2 months (at baseline and at the end of the treatment) |
| Changes in brain cortical electrical activity | Changes in the brain cortical electrical activity measured using quantitative electroencephalography (EEG) | 2 months (at baseline and at the end of the treatment) |
| Changes in global cognition | Addenbrooke's Cognitive Examination III | 2 months (at baseline and at the end of the study) |
| Changes in clinical impression of change | Caregiver's clinical impression of change (from 0 to 10) | 2 months |
| D001037 |
| Aphasia |
| D013064 | Speech Disorders |
| D007806 | Language Disorders |
| D003147 | Communication Disorders |
| D019954 | Neurobehavioral Manifestations |
| D009461 | Neurologic Manifestations |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D019965 | Neurocognitive Disorders |
| D001523 | Mental Disorders |