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Because of the expiration of the previous ethical approval documents
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The primary progressive aphasia (PPA) is a neurodegenerative condition characterized by a gradual, irreversible decline of language function (Mesulam, 2001). There are no known treatments for PPA so far. The relentless progression of PPA symptoms eventually leads to a profound impairment in communication ability and, ultimately, to more generalized deficits of cognition. Some cases and small studies reported that Transcranial Magnetic Stimulation (TMS), one of the non-invasive neuromodulation tech, can be employed to facilitate language production and improve the language ability in patients with PPA. Herein we will explore the tolerance and efficacy of TMS for the treatment of PPA by the randomized controlled trial .Meanwhile the functional MRI tech will be used to investigate the neural network changing in the procedure
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| rTMS treatment group | Experimental | The participants will be devided into rTMS treatment and sham treatment by means of randomized methods.The protocol of treatment is to use rTMS with high frequency 10/20Hz 120%RMT 20 times for one month. The device is Magtism rTMS made in London, UK |
|
| sham treatment group | Sham Comparator | The control group is to receive sham treatment. The device is the same as the one used in the real treatment group. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Magstim rTMS | Device | The device is made in London,UK |
|
| Measure | Description | Time Frame |
|---|---|---|
| Boston naming test evaluation | Assessment of the language production | Baseline |
| Boston naming test evaluation | Assessment of the language production | One month(just after 20 times rTMS treatment) |
| Western Aphasia Battery(WAB) Speech fluency | Assessment of the language production | Baseline |
| Western Aphasia Battery(WAB) Speech fluency | Assessment of the language production | One month(just after 20 times rTMS treatment) |
| Repetition Part of WAB | Assessment of the repetition ability | Baseline |
| Repetition Part of WAB | Assessment of the repetition ability | One month(just after 20 times rTMS treatment) |
| Word recognition Part of WAB | Assessment of the reading | Baseline |
| Word recognition Part of WAB | Assessment of the reading | One month(just after 20 times rTMS treatment) |
| Syntax comprehension Part of Bilingual Aphasia Battery( Standard modern Chinese version) |
| Measure | Description | Time Frame |
|---|---|---|
| fMRI parameters(strength, efficiency, clustering coefficient, and characteristic path length) | Graph theoretical analysis of the speech/language network | Baseline |
| fMRI parameters(strength, efficiency, clustering coefficient, and characteristic path length) |
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Inclusion Criteria:
All participants had also been evaluated previously by a behavioral neurologist at the Peking Union Medical College Hospital and had been clinically diagnosed with a variant of PPA.
Exclusion Criteria:
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| ID | Term |
|---|---|
| D018888 | Aphasia, Primary Progressive |
| ID | Term |
|---|---|
| D003704 | Dementia |
| D001927 | Brain Diseases |
| D002493 | Central Nervous System Diseases |
| D009422 | Nervous System Diseases |
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Assessment of the grammar ability |
| Baseline |
| Syntax comprehension Part of Bilingual Aphasia Battery( Standard modern Chinese version) | Assessment of the grammar ability | One month(just after 20 times rTMS treatment) |
Graph theoretical analysis of the speech/language network |
| One month(just after 20 times rTMS treatment) |
| D001037 |
| Aphasia |
| D013064 | Speech Disorders |
| D007806 | Language Disorders |
| D003147 | Communication Disorders |
| D019954 | Neurobehavioral Manifestations |
| D009461 | Neurologic Manifestations |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D019965 | Neurocognitive Disorders |
| D001523 | Mental Disorders |