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| Name | Class |
|---|---|
| University of Toronto | OTHER |
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The purpose of the study is to determine to what extent the abdominal muscles contribute to airway pressure, in order to investigate the correlation between muscles weakness and extubation outcome in mechanically ventilated patients. In addition the reliability of the sonographic measurements will be assessed.
The purpose of the study is to determine to what extent the abdominal muscles contribute to airway pressure, in order to investigate the correlation between muscles weakness and extubation outcome in mechanically ventilated patients. In addition the reliability of the sonographic measurements will be assessed.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Mechanically ventilated patients | Abdominal muscles ultrasound |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Abdominal muscles ultrasound | Diagnostic Test | Abdominal muscles ultrasound during a spontaneous breathing trial using the M-mode to calculate the thickening fraction of the anterior and lateral abdominal muscles under multiple circumstances (tasks performed by the patients) |
| Measure | Description | Time Frame |
|---|---|---|
| Correlation between thickening fraction and SBT outcome | Correlation between thickening fraction of each muscles evaluated by ultrasound before the SBT and the SBT outcome. | Measurements will be performed before SBT |
| Measure | Description | Time Frame |
|---|---|---|
| Correlation between the pressures generated by respiratory muscles and SBT outcome | Correlation between the pressures generated by respiratory muscles during the ultrasound measurements (Twice Transdiaphragmatic pressure, TwPdi; maximal inspiratory pressure, MIP) and SBT outcome | Measurements will be performed before SBT |
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Inclusion Criteria:
Exclusion Criteria:
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Patients Mechanically ventilated in ICU
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| Name | Affiliation | Role |
|---|---|---|
| Simone Piva, M.D. | University Of Brescia, Spedali Civili di Brescia | Study Director |
| Ewan Goligher, M.D. | University of Toronto | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Toronto General Hospital Research Institute | Toronto | ON M5G 2N2 | Canada | |||
| Spedali Civili di Brescia |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 34090872 | Derived | Schreiber AF, Bertoni M, Coiffard B, Fard S, Wong J, Reid WD, Brochard LJ, Piva S, Goligher EC. Abdominal Muscle Use During Spontaneous Breathing and Cough in Patients Who Are Mechanically Ventilated: A Bi-center Ultrasound Study. Chest. 2021 Oct;160(4):1316-1325. doi: 10.1016/j.chest.2021.05.053. Epub 2021 Jun 6. |
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| ID | Term |
|---|---|
| D018908 | Muscle Weakness |
| ID | Term |
|---|---|
| D009135 | Muscular Diseases |
| D009140 | Musculoskeletal Diseases |
| D020879 | Neuromuscular Manifestations |
| D009461 | Neurologic Manifestations |
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| Inter-rater agreement |
Concordance of measurements of abdominal muscle thickness and thickening fraction in mechanically ventilated patients performed by two different observers will be evaluated. |
| Measurements will be performed before SBT |
| Brescia |
| 25100 |
| Italy |
| D009422 | Nervous System Diseases |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D012816 | Signs and Symptoms |