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To investigate in vitro the effect of triglyceride rich lipoproteins (TGRL) obtained in type 2 diabetic women in the fasting state and following a randomized isocaloric lipid rich breakfast on control human platelets
Randomized Comparison of butter versus chocolate spread in 2 groups of 15 patients
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Butter based breakfast | Active Comparator |
| |
| Chocolate spread based breakfast | Active Comparator |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| butter based breakfast | Other | ingestion of proteins : 5 g, lipids 20 g, glucides 57 g |
|
| Measure | Description | Time Frame |
|---|---|---|
| fasting thromboxane B2 concentration | ex vivo experiment : TGRL obtained by preparative Unesterified cholesterol (UC) incubated with control human platelets | Hour 0 |
| after breakfast thromboxane B2 concentration | ex vivo experiment : TGRL obtained by preparative Unesterified cholesterol (UC) incubated with control human platelets | 4 hours |
| Measure | Description | Time Frame |
|---|---|---|
| measurement of fasting platelet activation by turbidimetric method | Hour 0 | |
| measurement of post prandial platelet activation by turbidimetric method | 4 Hours | |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Hôpital Louis Pradel - department of endocrinology | Bron | 69500 | France |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 32844550 | Result | Boulet MM, Cheillan D, Di Filippo M, Lelekov-Boissard T, Buisson C, Lambert-Porcheron S, Nazare JA, Tressou J, Michalski MC, Calzada C, Moulin P. Postprandial Triglyceride-Rich Lipoproteins from Type 2 Diabetic Women Stimulate Platelet Activation Regardless of the Fat Source in the Meal. Mol Nutr Food Res. 2020 Oct;64(19):e2000694. doi: 10.1002/mnfr.202000694. Epub 2020 Sep 9. |
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| ID | Term |
|---|---|
| D003924 | Diabetes Mellitus, Type 2 |
| ID | Term |
|---|---|
| D003920 | Diabetes Mellitus |
| D044882 | Glucose Metabolism Disorders |
| D008659 | Metabolic Diseases |
| D009750 | Nutritional and Metabolic Diseases |
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| Chocolate spread based breakfast | Other | ingestion of proteins 7 g, lipids 20 g, glucides 56 g |
|
| fasting lipidomic composition of triglyceride rich lipoproteins |
Characterization and comparison of LRT lipidomics in fasting DT2 patients and following the ingestion of a high-fat breakfast according to their source (short and medium chain fatty acids (butter) versus palmitic acid (palm oil present in spreads). |
| Hour 0 |
| post prandial lipidomic composition of triglyceride rich lipoproteins | Characterization and comparison of LRT lipidomics in fasting DT2 patients and following the ingestion of a high-fat breakfast according to their source (short and medium chain fatty acids (butter) versus palmitic acid (palm oil present in spreads). | 4 Hours |
| D004700 | Endocrine System Diseases |