Duloxetine Potentiates the Analgesic Efficacy of Intrathecal Morphine

Duloxetine Potentiates the Analgesic Efficacy of Intrathecal Morphine in Major Abdominal Cancer Surgery

Duloxetine is a serotonin-norepinephrine reuptake inhibitor primarily used for treatment of major depression and anxiety. Duloxetine also has been used in the treatment of chronic pain conditions, such as osteoarthritis and musculoskeletal pain. There are few studies examining its effect for acute pain. The objective of this study is to evaluate the analgesic effect of duloxetine combined with intrathecal morphine for patients subjected to major abdominal cancer surgery

Inclusion Criteria:

• adult patients, subjected to major abdominal cancer surgery

Exclusion Criteria:

• patients on chronic opioid therapy
• patients allergic to study drugs (duloxetine+morphine)
• patients have uncontrolled hypertension and or ischemic heart disease