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| Name | Class |
|---|---|
| Institut Pasteur of New Caledonia | UNKNOWN |
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The dengue, Zika and chikungunya arboviruses represent potentially severe infections to which the New Caledonian population is exposed. In the absence of specific treatment or vaccine, vector control remains the method of choice to limit their spread. However, the traditional methods of prevention and vector control measure today face their limits: mosquito resistance to insecticides, difficulty of access and destruction of breeding areas... The World Mosquito Program Noumea project is based on the artificial colonization of the mosquito vector Aedes aegypti by the endosymbiotic bacteria Wolbachia, which reduces its ability to transmit arboviruses. The breeding of mosquitoes carrying the bacterium Wolbachia in the laboratories of the Institut Pasteur of New Caledonia requires the use of human blood samples for mosquito gorging.
The objective of the research is to generate, maintain and amplify Aedes aegypti Caledonian lineages carrying the Wolbachia bacteria for the planned insect release program in Noumea.
The dengue, Zika and chikungunya arboviruses represent potentially severe infections to which the New Caledonian population is exposed. In the absence of specific treatment or vaccine, disease vector control remains the method of choice to limit their spread. However, the traditional methods of prevention and disease vector control must today face their limits: mosquito resistance to insecticides, difficulty of access and destruction of breeding areas... The World Mosquito Program Noumea project is based on the artificial colonization of the mosquito vector Aedes aegypti by the endosymbiotic bacterium Wolbachia, which reduces its ability to transmit arboviruses. The breeding of mosquitoes carrying the bacterium Wolbachia in the laboratories of the Institut Pasteur of New Caledonia requires the use of human blood samples for mosquito gorging.
The objective of the research is to generate, maintain and amplify Aedes aegypti Caledonian lineages carrying the bacterium Wolbachia for the planned insect release program in Noumea.
The establishment of Wolbachia in Aedes aegypti populations in Noumea should lead to the reduction of active transmission of dengue, Zika and chikungunya in the municipality.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Hemochromatosis or polycythemia patients | Blood samples from hemochromatosis or polycythemia patients requiring therapeutic bleeding that are not used in medical applications. Blood bag (volume of blood: from 450 to 500 mL). |
| |
| Healthy donors | Blood samples from healthy donors. Blood bag (volume of blood: from 450 to 500 mL). |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Blood donations of hemochromatosis or polycythemia patients | Other | Blood samples are from blood donations of hemochromatosis or polycythemia patients requiring therapeutic bleeding that are not used in medical applications. |
| Measure | Description | Time Frame |
|---|---|---|
| Generation of Aedes aegypti Caledonian lineages carrying the Wolbachia bacteria | Generation of Aedes aegypti Caledonian lineages carrying the Wolbachia bacteria for the planned insect release program in Noumea by measuring the Aedes aegypti female gorging rate | 36 months |
| Maintenance and amplification of Aedes aegypti Caledonian lineages carrying the Wolbachia bacteria | Maintenance and amplification of Aedes aegypti Caledonian lineages carrying the Wolbachia bacteria for the planned insect release program in Noumea by measuring the number of eggs per Aedes Aegypti female gorged | 36 months |
| Measure | Description | Time Frame |
|---|---|---|
| Vector competence assessment of the different Aedes aegypti Caledonian lineages | Assessment of the vector competence for the dengue, Zika and chikungunya viruses of the different Aedes aegypti Caledonian lineages with or without Wolbachia bacteria carriage by measuring the transmissibility reduction of Aedes aegypti carrying Wolbachia for arboviruses | 36 months |
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Inclusion Criteria:
Exclusion Criteria:
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Hemochromatosis or polycythemia patients requiring therapeutic bleeding that are not used in medical applications, and healthy donors.
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Vincent Richard | Contact | +687 27.26.66 | vrichard@pasteur.nc | |
| Nicolas Pocquet | Contact | +687 27.26.66 | npocquet@pasteur.nc |
| Name | Affiliation | Role |
|---|---|---|
| Frédéric Touzain | Hospital Center of New Caledonia | Principal Investigator |
| Myrielle Dupont-Rouzeyrol | Institut Pasteur of New Caledonia | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Centre Hospitalier de Nouvelle-Calédonie | Recruiting | Nouméa | Nouvelle-Calédonie | 98 849 | France |
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| ID | Term |
|---|---|
| D001102 | Arbovirus Infections |
| ID | Term |
|---|---|
| D000079426 | Vector Borne Diseases |
| D007239 | Infections |
| D014777 | Virus Diseases |
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| Blood donations of healthy donors | Other | Blood samples are from blood donations of healthy donors. |
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