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The investigator tried to find out possibility of functional improvement using botulinum toxin injection targeting finger flexor spasticity with functional electrical stimulation among chronic stroke patients who did not show any improvement in hand function.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Botulinum toxin type A injection | Experimental | Botulinum toxin type A injection followed by functional electrical stimulation |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Botulinum Toxin Type A 100 unit/Vial (Product) | Drug | Botulinum toxin type A injection followed by functional electrical stimulation |
|
| Measure | Description | Time Frame |
|---|---|---|
| Change in Box and Block test | number of box moved by affected upper extremity | baseline, 2 weeks after baseline, 6 weeks after baseline, 10 weeks after baseline |
| Change of Action Research Arm Test | Score of Action Research Arm Test | baseline, 2 weeks after baseline, 6 weeks after baseline, 10 weeks after baseline |
| Measure | Description | Time Frame |
|---|---|---|
| Muscle strength of finger extensor | Medical research council grading of muscle strength | baseline, 2 weeks after baseline, 6 weeks after baseline, 10 weeks after baseline |
| Spasticity of finger extensor |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Joon-Ho Shin, MS | National Rehabilitation Center of Korea | Principal Investigator |
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| Type | Date | Date Unknown |
|---|---|---|
| Release | Mar 11, 2019 | |
| Reset | Jun 13, 2019 | |
| Release | Apr 7, 2026 | |
| Reset | Apr 23, 2026 |
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| Release Date | Unrelease Date | Unrelease Date Unknown | Reset Date | MCP Release Number |
|---|---|---|---|---|
| Mar 11, 2019 | Jun 13, 2019 | |||
| Apr 7, 2026 |
| ID | Term |
|---|---|
| D020521 | Stroke |
| D006429 | Hemiplegia |
| ID | Term |
|---|---|
| D002561 | Cerebrovascular Disorders |
| D001927 | Brain Diseases |
| D002493 | Central Nervous System Diseases |
| D009422 | Nervous System Diseases |
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| ID | Term |
|---|---|
| D004364 | Pharmaceutical Preparations |
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|
Modified ashworth scale of finger flexor
| baseline, 2 weeks after baseline, 6 weeks after baseline, 10 weeks after baseline |
| active range of motion of wrist joint | active range of motion of wrist joint | baseline, 2 weeks after baseline, 6 weeks after baseline, 10 weeks after baseline |
| Brunnstrom stage of stroke recovery of distal upper extremity | Brunnstrom stage of stroke recovery of distal upper extremity. By observing the pattern of participants posture, the stage was scored. The stage ranges from 1 to 6. Higher is better. | baseline, 2 weeks after baseline, 6 weeks after baseline, 10 weeks after baseline |
| Distance from middle finger tip to mid-palmar crease | Distance from middle finger tip to mid-palmar crease | baseline, 2 weeks after baseline, 6 weeks after baseline, 10 weeks after baseline |
| Repeated number of finger extension and flexion | Repeated number of finger extension and flexion | baseline, 2 weeks after baseline, 6 weeks after baseline, 10 weeks after baseline |
| Quick Disabilities of Arm, Shoulder & Hand | Quick Disabilities of Arm, Shoulder & Hand is questionnaire about patients' symptoms as well as ability to perform certain activities in the last week. Total score is obtained by summing the each question, and ranges from 0 (no disability) to 100 (most severe disability). | baseline, 2 weeks after baseline, 6 weeks after baseline, 10 weeks after baseline |
| Grading of active thumb opposition | Grading of active thumb opposition. It is measured by observing the pattern of thumb opposition. | baseline, 2 weeks after baseline, 6 weeks after baseline, 10 weeks after baseline |
| Grip strength | measured by Jamar dynamometer | baseline, 2 weeks after baseline, 6 weeks after baseline, 10 weeks after baseline |
| Active finger extension | Active finger extension. It is graded by observation of voluntary finger extension. | baseline, 2 weeks after baseline, 6 weeks after baseline, 10 weeks after baseline |
| Apr 23, 2026 |
| D014652 | Vascular Diseases |
| D002318 | Cardiovascular Diseases |
| D010243 | Paralysis |
| D009461 | Neurologic Manifestations |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |