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The purpose of this study is to see if there is a difference between the development of the brain (neurodevelopment) in children who have been treated for retinoblastoma with multiple anesthetic exposures, compared with brain development in children who have never had anesthesia.
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Wechsler Intelligence Scale for Children, Fifth Edition (WISC-V) | Other | the WISC-V assessment produces a Full Scale IQ (FSIQ) used for primary power consideration in this study. The FSIQ is the most comprehensive global ability score on the WISC-V, and it has been conventionally reported and interpreted as an estimation of overall intellectual ability | ||
| California Verbal Learning Test, Children's Version | Other | Used to assess verbal learning and memory in children and adolescents | ||
| Beery Developmental Test of Visual Motor Integration, 6th edition | Other | Helps assess visual-motor skills in children and adults. | ||
| Grooved Pegboard Test | Other | Measures dexterity | ||
| Behavior Assessment System for Children/Parent Report | Other | The Behavior Assessment System for Children/Parent Report is a questionnaire that assesses the social-emotional and behavioral functioning (e.g., anxiety, depression, attention, hyperactivity, adaptability, leadership, social skills, etc.) in children between the ages of 2 and 22 years, and is available in English and Spanish. |
| Measure | Description | Time Frame |
|---|---|---|
| Comparing scores in neuropsychological testing results | The primary outcome is based on the Wechsler Intelligence Scale for Children, 5th edition (WISC-V) measured at follow up. The 5 primary index scores on the WISC-V (Verbal Comprehension, Visual Spatial, Fluid Reasoning, Working Memory, and Processing Speed) are based on 10 subtests and represent intellectual functioning in different cognitive areas. Similar to the FSIQ, the primary index scores are on a standard score metric with a mean of 100 (SD=15). The WISC-V consists of 16 subtests; each subtest is based on a scaled score metric with a mean of 10 and standard deviation (SD) of 3. Performance on these domain-specific subtests will be summarized and analyzed similarly to the FSIQ. | 6 weeks |
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Inclusion Criteria:
Exclusion Criteria:
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pediatric patients with retinoblastoma, between 6 and 16 years of age, at MSK.
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Vittoria Arslan Carlon, MD | Contact | 212-639-2680 | arslancv@mskcc.org | |
| David Abramson, MD | Contact | 212-639-7232 | abramsod@mskcc.org |
| Name | Affiliation | Role |
|---|---|---|
| Vittoria Arslan Carlon, MD | Memorial Sloan Kettering Cancer Center | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Memorial Sloan Kettering Cancer Center | Recruiting | New York | New York | 10065 | United States |
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| Label | URL |
|---|---|
| Memorial Sloan Kettering Cancer Center | View source |
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| ID | Term |
|---|---|
| D012175 | Retinoblastoma |
| ID | Term |
|---|---|
| D018302 | Neoplasms, Neuroepithelial |
| D017599 | Neuroectodermal Tumors |
| D009373 | Neoplasms, Germ Cell and Embryonal |
| D009370 | Neoplasms by Histologic Type |
| D009369 | Neoplasms |
| D009375 | Neoplasms, Glandular and Epithelial |
| D009380 | Neoplasms, Nerve Tissue |
| D019572 | Retinal Neoplasms |
| D005134 | Eye Neoplasms |
| D009371 | Neoplasms by Site |
| D015785 | Eye Diseases, Hereditary |
| D005128 | Eye Diseases |
| D012164 | Retinal Diseases |
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| ID | Term |
|---|---|
| D014888 | Wechsler Scales |
| D000073219 | Memory and Learning Tests |
| ID | Term |
|---|---|
| D007361 | Intelligence Tests |
| D001077 | Aptitude Tests |
| D011581 | Psychological Tests |
| D004191 | Behavioral Disciplines and Activities |
| D009483 | Neuropsychological Tests |
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