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The infantile brain has to pass essential, mayor steps in the first 36 months of life. During that period of development it is particularly vulnerable to toxic, exogenic influences. This study wants to review the long-term effects of children who were exposed to anesthesia in the first three years of their life. Therefore the investigators will examine children at age of 4-10 that were exposed to anesthesia and compare their neurocognitive capacity to children who did not have any exposure to anesthesia. The investigators plan on measuring the intelligence quotient using standardized tests which will be performed by a trained psychologist. In addition there will be a questionnaire concerning behavioral characteristics and educational development which is filled by the parents. The exposed children will be recruited from our preexisting database, the control group will be recruited from practitioners and the pediatric walk-in-clinic.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Exposed | Children age 4-10 who required general anesthesia before the age of 36 months in the context of surgical and diagnostic procedures or sedation during intensive care, excluding neurosurgical interventions or cardiac surgery as well as preexisting hereditary or acquired neurocognitive deficits | ||
| Control | Children age 4-10 who did not require any anesthesia before the age of 36 months. Excluding preexisting hereditary or acquired neurocognitive deficits. |
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| Measure | Description | Time Frame |
|---|---|---|
| Cognitive Capacity for children between 7 and 10 years of age | Standardized tests for intelligence quotient (IQ): Kaufman Assessment Battery for Children - Second Edition (KABC-II) | Test is done 1 to 10 years after anesthesia and is lasting 3 hours |
| Cognitive Capacity for children between 4 and 7 years of age | Standardized tests for intelligence quotient (IQ): Wechsler Preschool and Primary Scale of Intelligence (WPPSI-III) | Test is done 1 to 10 years after anesthesia and is lasting 3 hours |
| Cognitive Capacity for children between 2 and 4 years of age | Standardized tests for intelligence quotient (IQ): Wechsler Intelligence Scale for Children (WISC-IV) | Test is done 1 to 10 years after anesthesia and is lasting 3 hours |
| Measure | Description | Time Frame |
|---|---|---|
| Educational status | Questionnaire, filled by parents 1-10 years after anesthesia exposure | 1 to 10 years after anesthesia, lasting 30 minutes |
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Inclusion Criteria:
Exclusion Criteria:
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Children age 4-10 who underwent general anesthesia below the age of 36 months in context of surgical or diagnostic procedures or sedation uring intensive care.
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University Hospital | Erlangen | Bavaria | 91054 | Germany |
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