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The purpose of this study is to assess and validate the clinical criteria of sensitization ("Convergences PP criteria") selected by the expert consensus with neurophysiological sensory testing.
Some patient with chronic pelvic or perineal pain, present complex manifestations, comprising pain and dysfunction which does not involved a single organ. The gap between clinical symptoms and pathological signs is a constant feature of these pain syndromes. A possible explanation for these pain syndromes is central sensitization. This sensitization is defined by decrease nociceptive thresholds, a more intense and more prolonged response to nociceptive stimulus, and spatial extension of the painful area. It has been defined by international expert consensus in 2016 a clinical evaluation tool with 10 criteria for sensitization diagnosis: Convergences PP criteria. The aim of this study is to objectivize lower threshold, spatial and temporal diffusion of pain in women with chronic pelvic or perineal pain with sensitization (Convergences PP criteria > 5) compared to women without sensitization (Convergences PP criteria < 5). A sensory testing of lower urinary tract, lower rectal tract, vulva and pelvic muscles will be achieved.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Patient with pelvic or perineal pain with sensitization | Other | Patients with chronic pelvic or perineal pain with sensitization (Convergences PP criteria > 5) |
|
| Patient with pelvic or perineal pain without sensitization | Other | Patients with chronic pelvic or perineal pain without sensitization (Convergences PP criteria < 5) |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Sensory testing of lower urinary tract. | Other | Non invasive lower urinary tract sensitivity testing: provoked diuresis with sonographic estimates of sensory thresholds. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Comparison of pelvic pain threshold | Comparison of pelvic pain threshold obtained by 4 neurophysiological testing, between women with chronic pelvic or perineal pain with sensitization (Convergences PP criteria > 5) and without sensitization (Convergences PP criteria < 5). | 1 month after inclusion in the study |
| Measure | Description | Time Frame |
|---|---|---|
| Identification of temporal distribution of pain | Identification of temporal distribution of pain in women with chronic pelvic or perineal pain with sensitization (Convergences PP criteria > 5) compared to women without sensitization (Convergences PP criteria < 5). | 1 month after inclusion in the study |
| Identification of lower pain perception thresholds |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Nantes university Hospital | Nantes | 44093 | France | |||
| Groupe Confluent |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 37516398 | Derived | Cardaillac C, Levesque A, Riant T, Mortier A, Neunlist M, Perrouin-Verbe MA, Volteau C, Thubert T, Brochard C, Ploteau S. Evaluation of a scoring system for the detection of central sensitization among women with chronic pelvic pain. Am J Obstet Gynecol. 2023 Nov;229(5):530.e1-530.e17. doi: 10.1016/j.ajog.2023.07.044. Epub 2023 Jul 27. |
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2 types of patients will be included:
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| Sensory testing of lower rectal tract | Other | Lower digestive tract sensitivity testing: rectal electronic barostat with ascending pressure (phasic distension). |
|
| Sensory testing of vulva muscles | Other | Vulvar sensitivity testing: pressure pain threshold evaluated using vulvagesiometer. |
|
| Sensory testing of pelvic muscles | Other | Myofascial sensitivity testing: piriformis, levator ani and obturator internus muscles pressure pain threshold evaluated using intra-vaginal algometer. |
|
Identification of lower pain perception thresholds in women with chronic pelvic or perineal pain with sensitization (Convergences PP criteria > 5) compared to women without sensitization (Convergences PP criteria < 5) for each of the 4 neurophysiological testing. |
| 1 month after inclusion in the study |
| Comparison of state anxiety | Comparison of state anxiety between women with chronic pelvic or perineal pain with sensitization (Convergences PP criteria > 5) and without sensitization (Convergences PP criteria < 5). | 1 month after inclusion in the study |
| Comparison of depression | Comparison of depression between women with chronic pelvic or perineal pain with sensitization (Convergences PP criteria > 5) and without sensitization (Convergences PP criteria < 5). | 1 month after inclusion in the study |
| Comparison of catastrophizing | Comparison of catastrophizing between women with chronic pelvic or perineal pain with sensitization (Convergences PP criteria > 5) and without sensitization (Convergences PP criteria < 5). | 1 month after inclusion in the study |
| Comparison of quality of life | Comparison of quality of life between women with chronic pelvic or perineal pain with sensitization (Convergences PP criteria > 5) and without sensitization (Convergences PP criteria < 5). | 1 month after inclusion in the study |
| Nantes |
| 44277 |
| France |