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Patients with inflammatory bowel disease (IBD) often suffer from muscle weakness and a low bone mineral density as a consequence of systemic Inflammation and disease treatment limiting Quality of life in a considerable way. Exercise interventions to build up muscle mass and increasing physical function are promising Tools to improve the whole muscular Status of those patients. However, in the acute Phase of IBDs conventional Training methods may be too strenous, also because patients are suffering from acute gastrointestinal symptoms and feel fatigued. Due to those symptoms, patients present low Food intake and great loss of nutrients and energy especially by diarrhea. Individualized nutritional Support may be helpful to avoid malnutrition. The aim of this pilot study is to investigate the effect of a combined exercise and Nutrition Intervention using the gentle Training method of whole-body electromyostimulation (WB-EMS) combined with a individual high Protein nutritional Support on muscle mass, Body composition, physical function, Quality of life and gastrointestinal symptoms in outpatients with IBD.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Control group | No Intervention | usual care treatment | |
| Nutrition | Experimental | high-protein nutrition therapy |
|
| EMS+Nutrition | Experimental | WB-EMS Training (2x/week á 20 min) + high-protein nutrition therapy |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| WB-EMS | Other | WB-EMS training is performed 2x/week for 12 weeks; Stimulation protocol: Frequency of 85 Hz, pulse duration of 0.35 ms, stimulation period of 6 sec, resting period of 4 sec; supervised by certified training instructors/physiotherapists participants perform simple exercises during the stimulation period following a video tutorial |
| Measure | Description | Time Frame |
|---|---|---|
| Skeletal muscle mass | assessed by bioelectrical impedance analysis in kg | 12 weeks |
| Measure | Description | Time Frame |
|---|---|---|
| Body composition | assessed by bioelectrical impedance analysis in kg or % | 12 weeks |
| Physical function - isometric muscle strength | isometric hand grip strength assessed by hand dynamometer |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Universitätsklinikum Erlangen, Medizinische Klinik 1 | Recruiting | Erlangen | Bavaria | 91054 | Germany |
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| ID | Term |
|---|---|
| D015212 | Inflammatory Bowel Diseases |
| D018908 | Muscle Weakness |
| D003424 | Crohn Disease |
| D003093 | Colitis, Ulcerative |
| ID | Term |
|---|---|
| D005759 | Gastroenteritis |
| D005767 | Gastrointestinal Diseases |
| D004066 | Digestive System Diseases |
| D007410 | Intestinal Diseases |
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| ID | Term |
|---|---|
| D018529 | Nutritional Support |
| ID | Term |
|---|---|
| D044623 | Nutrition Therapy |
| D013812 | Therapeutics |
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|
| Nutritional support | Other | dietary monitoring by dietary records; nutritional counselling by dietician, dietary advices: 1.5 g/kg bodyweight/day |
|
| 12 weeks |
| Physical function - Endurance | Six-minute-walk test (walking distance in m) | 12 weeks |
| Physical function - lower limb strength | isometric lower limb strength assessed by isometric force plates in N | 12 weeks |
| Quality of Life | IBDQ-D | 12 weeks |
| Physical activity | IPAQ | 12 weeks |
| Disease activity (Crohn's disease) | Harvey Bradshaw Index | 12 weeks |
| Disease activity (ulcerative colitis) | Mayo Score | 12 weeks |
| Inflammation status | C-reactive protein (CRP) | 12 weeks |
| D009135 | Muscular Diseases |
| D009140 | Musculoskeletal Diseases |
| D020879 | Neuromuscular Manifestations |
| D009461 | Neurologic Manifestations |
| D009422 | Nervous System Diseases |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D012816 | Signs and Symptoms |
| D003092 | Colitis |
| D003108 | Colonic Diseases |