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The aim of this study is to investigate the effect of overnight fasting versus a diurnal fasting (during daily life activities) in females with and without obesity on inflammation, neurotrophins, energy metabolism, mood, food cravings, and appetite sensations.
This study will be an acute fasting intervention.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Acute fasting | Experimental | Participants will fast overnight for 10 hours (resting period), consume a santdardized breakfast, and fast during daily activities (active period) for another 10 hours. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Acute Fasting | Other | The volunteers will fast overnight (10 hours) and breakfast will be offered (bread, butter, ham and industrialized fruit juice). The participants will fast for another 10 hours during daily activities. |
| Measure | Description | Time Frame |
|---|---|---|
| Blood glucose | Changes in blood glucose will be assessed at baseline and after 10 hours of fasting during daily activities | At baseline (after overnight fasting) and end (after 10 hours of fasting during the day) of the intervention period (~12 hours) |
| Lipid panel | Changes in lipid panel (i.e. total cholesterol, LDL, HDL and triglycerides) will be assessed at baseline and after 10 hours of fasting during daily activities | At baseline (after overnight fasting) and end (after 10 hours of fasting during the day) of the intervention period (~12 hours) |
| Interleukin 6 | Changes in blood interleukin-6 will be assessed at baseline and after 10 hours of fasting during daily activities | At baseline (after overnight fasting) and end (after 10 hours of fasting during the day) of the intervention period (~12 hours) |
| Appetite sensations | Changes in hunger, satiety, fullness, and prospective food consumption will be assessed at baseline and after 10 hours of fasting during daily activities using a 100 mm visual analogue scale | At baseline (after overnight fasting) and end (after 10 hours of fasting during the day) of the intervention period (~12 hours) |
| Mood states | Changes in anger, confusion, depression, fatigue, tension, and vigor will be assessed using the Brunel Mood Scale | At baseline (after overnight fasting) and end (after 10 hours of fasting during the day) of the intervention period (~12 hours) |
| Measure | Description | Time Frame |
|---|---|---|
| Gastrointestinal peptides | Changes in resting energy expenditure will be assessed at baseline and after 10 hours of fasting during daily activities using indirect calorimetry | At baseline (after overnight fasting) and end (after 10 hours of fasting during the day) of the intervention period (~12 hours) |
| Free fatty acids |
| Measure | Description | Time Frame |
|---|---|---|
| High-sensitivity C-reactive protein | Changes in blood high-sensitivity C-reactive protein will be assessed at baseline and after 10 hours of fasting during daily activities | At baseline (after overnight fasting) and end (after 10 hours of fasting during the day) of the intervention period (~12 hours) |
| Tumor necrosis factor-α |
Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Adaliene Versiani Matos Ferreira, PhD | Federal University of Minas Gerais | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Hospital das Clínicas da Universidade Federal de Minas Gerais | Belo Horizonte | Minas Gerais | 30130-100 | Brazil |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 40491423 | Derived | Tibaes JRB, Fagundes GB, Martins LB, Rodrigues AMDS, Campos AC, de Souza Cordeiro LM, Teixeira AL, Ferreira AVM. Effects of a single 10-hour daytime fasting intervention on mood and appetite in female adults with and without obesity: a real-world feasibility trial. Nutr Neurosci. 2025 Nov;28(11):1372-1385. doi: 10.1080/1028415X.2025.2514490. Epub 2025 Jun 10. |
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| ID | Term |
|---|---|
| D009765 | Obesity |
| ID | Term |
|---|---|
| D050177 | Overweight |
| D044343 | Overnutrition |
| D009748 | Nutrition Disorders |
| D009750 | Nutritional and Metabolic Diseases |
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Changes in free fatty acids will be assessed at baseline and after 10 hours of fasting during daily activities |
| At baseline (after overnight fasting) and end (after 10 hours of fasting during the day) of the intervention period (~12 hours) |
| Neurotrophic factors | Changes in brain-derived neurotrophic factor (BDNF), glial cell line-derived neurotrophic factor (GDNF), and nerve growth factor (NGF) will be assessed at baseline and after 10 hours of fasting during daily activities | At baseline (after overnight fasting) and end (after 10 hours of fasting during the day) of the intervention period (~12 hours) |
Changes in tumor necrosis factor-α will be assessed at baseline and after 10 hours of fasting during daily activities |
| At baseline (after overnight fasting) and end (after 10 hours of fasting during the day) of the intervention period (~12 hours) |
| Interleukin 8 | Changes in blood interleukin 8 will be assessed at baseline and after 10 hours of fasting during daily activities | At baseline (after overnight fasting) and end (after 10 hours of fasting during the day) of the intervention period (~12 hours) |
| Interleukin 10 | Changes in blood interleukin 10 will be assessed at baseline and after 10 hours of fasting during daily activities | At baseline (after overnight fasting) and end (after 10 hours of fasting during the day) of the intervention period (~12 hours) |
| Insulin | Changes in insulin will be assessed at baseline and after 10 hours of fasting during daily activities | At baseline (after overnight fasting) and end (after 10 hours of fasting during the day) of the intervention period (~12 hours) |
| Neutrophil/leukocyte ratio (NLR) | Changes in NLR will be assessed at baseline and after 10 hours of fasting during daily activities | At baseline (after overnight fasting) and end (after 10 hours of fasting during the day) of the intervention period (~12 hours) |
| Resting energy expenditure | Changes in resting energy expenditure will be assessed at baseline and after 10 hours of fasting during daily activities using indirect calorimetry | At baseline (after overnight fasting) and end (after 10 hours of fasting during the day) of the intervention period (~12 hours) |
| D001835 |
| Body Weight |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |