Chronic Effect of Fasting

Comparison of Weight Loss Induced by Daily Time-Restricted Feeding Versus Daily Caloric Restriction in Women With Overweight and Obesity

The aim of the study is to determine if time-restricted feeding (TRF) is an effective dietary strategy to weight loss after 8 weeks intervention. TRF will be compared with an intervention without restriction in time for feeding. Both strategies will be with caloric restriction.

The participants of the study will be divided in two groups: (1) a group with caloric restriction and without restriction in time for feeding and (2) a group with caloric restriction and restriction in time for feeding. This second group will be subdivided according to the participant's preference: (2.1) first meal at 8 a.m. and last meal at 4 p.m. or (2.2) first meal at 12 p.m. and last meal at 8 p.m. The caloric restriction for all participants will be 513 to 770 kcal from estimated energy requirement.

Inclusion Criteria:

• Females;
• Aged between 18 and 59 years old;
• Body mass index equal or greater 25 kg/m²;
• Agree to sign the informed consent.

Exclusion Criteria:

• Any chronic health conditions (e.g. chronic renal failure, autoimmune, heart, and liver disease);
• Thyroid diseases or medications for its treatment;
• Medications known to affect total energy expenditure;
• Use of steroids, immunosuppressants or non-steroidal anti-inflammatory drugs, weight-loss medications, oral hypoglycemic agents or insulin and any medications that influence metabolic and/or inflammatory parameters;
• Previous surgery for weight loss;
• Pregnancy or breast-feeding;
• Smoking;
• Alcohol use (>2 doses/day).