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| Name | Class |
|---|---|
| Department of Anesthesiology and Intensive Care, F. Chopin Hospital in Rzeszów | UNKNOWN |
| Department of Anesthesiology and Intensive Care, J. Śniadecki Hospital in Białystok | UNKNOWN |
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Oxycodone consumption and postoperative pain intensity in patients undergoing nephrectomy procedures. Of all study participants, 50% will obtain quadratus lumborum block (QLB).
Patients undergoing nephrectomy procedures will be allocated to one of the study arms. At the end of an operation, still under general anesthesia, 50% patients will obtain QLB with ropivacaine.
Ultrasound-guided QLB will be performed on the side of surgery with 0.375% ropivacaine solution (0.2 mL per kg).
Every patient will get patient-controlled analgesia pump with oxycodone in the postoperative period.
Postoperative pain will be measured with VAS (visual-analogue scale) 2, 4, 8, 12 and 24 hours after the end of the operation. 24 -hours period.
At the 1, 3, 6 months patients will be interviewed by phone to assess neuropathic pain. Neuropathic Pain Symptom Inventory (NPSI) will be used.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| QLB | Experimental | At the end of surgery, QLB with ropivacaine will be done on the side of the operation. |
|
| Control | Experimental | Standard care. No regional blocks. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| QLB | Procedure | On the side of the surgery, QLB with 0.375% ropivacaine (0.2 mL/kg) |
| |
| Measure | Description | Time Frame |
|---|---|---|
| Total consumption of oxycodone | Overall use of oxycodone administered by PCA pump will be assessed. | 24 hours after the end of surgery. |
| Measure | Description | Time Frame |
|---|---|---|
| Pain intensity | Pain intensity measured on VAS scale at the 2, 4, 8, 12, 24 hours. VAS in milimmeters. Minimum value 0, maximum 100. Less better - less severe pain. 0 no pain at all. | 24 hours after the end of surgery |
| Chronic pain |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Department of Anesthesiology and Intensive Care, J. Śniadecki Hospital in Białystok | Bialystok | 15-950 | Poland | |||
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| ID | Term |
|---|---|
| D010149 | Pain, Postoperative |
| ID | Term |
|---|---|
| D011183 | Postoperative Complications |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D010146 | Pain |
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| ID | Term |
|---|---|
| D010323 | Passive Cutaneous Anaphylaxis |
| D010098 | Oxycodone |
| D000077149 | Sevoflurane |
| D005283 | Fentanyl |
| D000077123 | Rocuronium |
| ID | Term |
|---|---|
| D012882 | Skin Tests |
| D007159 | Immunologic Tests |
| D019411 | Clinical Laboratory Techniques |
| D019937 | Diagnostic Techniques and Procedures |
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Patients will be randomly allocated to one of the study arms: QLB or control group.
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A regional block will be performed under general anesthesia. Patients will not be aware of this procedure.
| PCA |
| Device |
Patient-controlled analgesia |
|
| GA | Procedure | General anesthesia |
|
| Oxycodone | Drug | administered by PCA |
|
| Sevoflurane | Drug | Inhalational anesthetic during GA |
|
| Fentanyl | Drug | painkiller during GA |
|
| Rocuronium | Drug | muscle relaxant during GA |
|
Chronic pain occurrence assessed with Neuropathic Pain Symptom Inventory (NPSI) 10 descriptive variables, each one from 0 to 10. 0 means no pain. 10 very high chance of occurrence of neuropathic pain.
| 6 months after the surgery |
| Department of Anesthesiology and Intensive Care, F. Chopin Hospital in Rzeszów |
| Rzeszów |
| 35-055 |
| Poland |
| D009461 | Neurologic Manifestations |
| D012816 | Signs and Symptoms |
| D003933 | Diagnosis |
| D008919 | Investigative Techniques |
| D007158 | Immunologic Techniques |
| D000937 | Antigen-Antibody Reactions |
| D055633 | Immune System Phenomena |
| D003061 | Codeine |
| D009022 | Morphine Derivatives |
| D009019 | Morphinans |
| D053610 | Opiate Alkaloids |
| D000470 | Alkaloids |
| D006571 | Heterocyclic Compounds |
| D006572 | Heterocyclic Compounds, Bridged-Ring |
| D006576 | Heterocyclic Compounds, 4 or More Rings |
| D000072471 | Heterocyclic Compounds, Fused-Ring |
| D010616 | Phenanthrenes |
| D011084 | Polycyclic Aromatic Hydrocarbons |
| D011083 | Polycyclic Compounds |
| D008738 | Methyl Ethers |
| D004987 | Ethers |
| D009930 | Organic Chemicals |
| D006845 | Hydrocarbons, Fluorinated |
| D006846 | Hydrocarbons, Halogenated |
| D006838 | Hydrocarbons |
| D010880 | Piperidines |
| D006573 | Heterocyclic Compounds, 1-Ring |
| D000732 | Androstanols |
| D000731 | Androstanes |
| D013256 | Steroids |
| D000072473 | Fused-Ring Compounds |