Utility of Sodium Lactate Infusion During Septic Shock

Utility of Sodium Lactate Infusion During Septic Shock: Pilot Study

ULIS-1 is an open-label pilot study concerning utility of molar sodium lactate in fluid balance in septic shock patients

ULIS-1 consists in three arms of treatment during the first 24hrs of septic shock treatment.

• normal saline
• sodium lactate 2.5ml/kg in 60min then
• either 0.25 or 0.5ml/kg/h during 24hrs Main criteria is fluid balance at 48hrs

Inclusion Criteria:

• Presence of septic shock
• requiring vascular filling within 12 hours after introduction of Noradrenaline. Septic shock is defined as sepsis with persistent hypotension requiring the administration of vasopressors to maintain RTE > 65mmHg.
• social insurance

Exclusion Criteria:

• pregnancy
• cardiac arrest
• more than 50ml/kg of fluid loading
• chronic renal failure with chronic hemodialysis or the investigators estimate a need for renal replacement therapy in the following 24hrs
• child C or acute liver failure with PT<40% (unless AVK)
• plasmatic sodium <120 or >145mmol/l
• metabolic alkalosis with pH>7.45