Lactated Ringer Versus Albumin in Early Sepsis Therapy | NCT01337934 | Trialant

Lactated Ringer Versus Albumin in Early Sepsis Therapy | NCT01337934 | Trialant

Arms/Interventions Module

Arm Groups

Label	Type	Description	Intervention Names
Lactated Ringer	Placebo Comparator	Patients randomized for this group will receive 500 ml of lactated Ringer solution in early phase of sepsis or septic shock (less than six hour from sepsis onset) if mean arterial pressure was under 65mmHg, or blood lactate concentration higher than 4 mmol/L or base excess under - 4mmol/L until the target of central venous pressure of 8 mmHg or higher or recovery of hypotension.	Drug: Lactated Ringer
Albumin	Active Comparator	Patients randomized for Albumin group will receive 500 ml of 4% Albumin solution in early phase of sepsis (less than six hour from sepsis onset) if mean arterial pressure was under 65mmHg or blood lactate concentration higher than 4 mmol/L or base excess under - 4mmol/L until the target of central venous pressure of 8 mmHg or higher or recovery of hypotension.	Drug: Albumin

Outcomes Module

Contacts/Locations Module

Overall Officials

Name	Affiliation	Role
Juliano A Almeida, MD	University of Sao Paulo	Study Chair
Ludhmila Hajjar, PhD	University of Sao Paulo	Study Director
Clarice H Park, MD	University of Sao Paulo	Principal Investigator

References Module

Citations

PubMed Identifier	Type	Citation	Retractions
20940381	Background	Hajjar LA, Vincent JL, Galas FR, Nakamura RE, Silva CM, Santos MH, Fukushima J, Kalil Filho R, Sierra DB, Lopes NH, Mauad T, Roquim AC, Sundin MR, Leao WC, Almeida JP, Pomerantzeff PM, Dallan LO, Jatene FB, Stolf NA, Auler JO Jr. Transfusion requirements after cardiac surgery: the TRACS randomized controlled trial. JAMA. 2010 Oct 13;304(14):1559-67. doi: 10.1001/jama.2010.1446.

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