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The study purpose is to evaluate the morphological, functional and electrophysiological characteristics of the right ventricle before and after ajmaline in patients diagnosed with Brugada syndrome as well as to correlate CMR findings and substrate size.
All consecutive patients with either spontaneous or ajmaline-induced BrS-ECG pattern will be screened. A total of 30 BrS patients and 30 normal age, sex and BSA matched normal controls will be selected and enrolled. Patients will perform cardiac magnetic resonance imaging to evaluate and compare morphological and functional characteristics of the 2 groups before and after ajmaline. BrS patients will also perform a standardized programmed ventricular stimulation protocol and electroanatomical mapping to determine the substrate size.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| BrS Group | Ajmaline 17-(Chloroacetate) Monohydrochloride |
| |
| No BrS group | Ajmaline 17-(Chloroacetate) Monohydrochloride |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Ajmaline 17-(Chloroacetate) Monohydrochloride | Drug | Ajmaline 17-(Chloroacetate) Monohydrochloride(1mg/kg in 5 minutes) |
|
| Measure | Description | Time Frame |
|---|---|---|
| Electrocardiographic changes | Changes of PR, QRS, and QT parameters, before and after ajmaline in Brugada patients as compared with control subjects | 1 day during Electrocardiography |
| MRI changes of left and right ventricular function | MRI changes of left and right ventricular function before and after ajmaline in Brugada patients as compared with control subjects | 1day during MRI |
| CMR parameters changes of the right and left ventricle function | Changes of right ventricular areal strain before and after ajmaline in Brugada patients as compared with controls | 1 day during CMR |
| Electrical substrate changes of the right ventricle | electroanatomical epicardial mapping for substrate determination before and after ajmaline | 1 day after ICD implantation |
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Inclusion Criteria:
Exclusion Criteria:
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A total of 60 selected subjects (30 BrS patients and 30 normal controls) will be enrolled.
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| Name | Affiliation | Role |
|---|---|---|
| Carlo Pappone, MD | IRCCS San Donato University Hospital Policlinico San Donato, Milan, Italy | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| IRCCS Policlinico S. Donato | San Donato Milanese | Milano | 20097 | Italy |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 34693720 | Derived | Pappone C, Santinelli V, Mecarocci V, Tondi L, Ciconte G, Manguso F, Sturla F, Vicedomini G, Micaglio E, Anastasia L, Pica S, Camporeale A, Lombardi M. Brugada Syndrome: New Insights From Cardiac Magnetic Resonance and Electroanatomical Imaging. Circ Arrhythm Electrophysiol. 2021 Nov;14(11):e010004. doi: 10.1161/CIRCEP.121.010004. Epub 2021 Oct 25. |
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| ID | Term |
|---|---|
| D053840 | Brugada Syndrome |
| ID | Term |
|---|---|
| D001145 | Arrhythmias, Cardiac |
| D006331 | Heart Diseases |
| D002318 | Cardiovascular Diseases |
| D000075224 | Cardiac Conduction System Disease |
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| ID | Term |
|---|---|
| D064794 | Lorajmine |
| ID | Term |
|---|---|
| D000404 | Ajmaline |
| D046948 | Secologanin Tryptamine Alkaloids |
| D026121 | Indole Alkaloids |
| D000470 | Alkaloids |
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| D030342 | Genetic Diseases, Inborn |
| D009358 | Congenital, Hereditary, and Neonatal Diseases and Abnormalities |
| D006571 |
| Heterocyclic Compounds |
| D007211 | Indoles |
| D006574 | Heterocyclic Compounds, 2-Ring |
| D000072471 | Heterocyclic Compounds, Fused-Ring |
| D054836 | Indolizidines |
| D007212 | Indolizines |