The Response To Ajmaline Provocation in Healthy Subjects

An Observational Study Into the Variety of Electrocardiographic Responses to an Ajmaline Provocation in a Healthy Subjects. What Are the Genetic and Structural Variations Dictating This Response ?

Standard, high lead and sodium channel provoked electrocardiograms of a healthy volunteers will be performed to observe the various ECG changes. Participants will the undergo detailed imaging with cardiac magnetic resonance imaging and deep genotyping to identify structural or genetic variants which might dictate the electrocardiographic patterns at rest and with sodium channel provocation.

The investigators will recruit healthy subjects without a history of cardiac symptoms or a family history of sudden death or premature arrhythmogenic cardiac disease. Participants will undergo electrocardiographic phenotype assessment with standard and high lead electrocardiogram and sodium channel provocation. Detailed cardiac structural examination will be performed with cardiac magnetic resonance imaging to look for any variation in mainly right ventricular outflow tract structure and myocardial architecture. Participants will also undergo targeted genomic sequencing to look for variations in genes encoding for cardiac sodium channel.

Inclusion Criteria:

• Asymptomatic healthy Volunteers

Exclusion Criteria:

• • Any prior cardiovascular illness

  • Previous cardiac symptoms.
  • History of unexplained syncope
  • Any family history of proven sudden cardiac death or unexplained sudden death either in adulthood or infancy.
  • Those unable to provide a two generation family history
  • Abnormal resting ECG
  • Any contraindications to cardiac magnetic resonance imaging
  • Pregnant or breastfeeding women
  • Intercurrent use of any medication known to be contraindicated in Brugada Syndrome