Study of Dysarthria, and the Appearance of Non-dopaminergic Signs in Idiopathic PARKinson's Disease

Prospective Study of Dysarthria, and the Appearance of Non-dopaminergic Signs in Idiopathic PARKinson's Disease

Pilot study:

• Longitudinal follow up of the PRODY-GI cohort for parkinson's disease (PD)
• Observational study of upper and lower axial symptoms' occurence in 30 PD patients in on and off drug conditions, 30 aged matched control subjects and 10 control subjects with supra nuclear palsy
• Multi modal approach: functional MRI, clinical , ENT assessment, respiratory assessment, neuropsychological and gait evaluations

Prospective, clinical assessment of :

• Cognition and diadochokinetic task during fMRI in 30 PD patients (in off and on condition)
• Motor assessment using VICON gait and balance analysis
• Pulmonary functional testing in OFF and ON drug condition
• Quality of life
• Clinical neurological MDS UPDRS , N Fog questionnaire
• ENT and speech therapist evaluation in OFF and ON drug condition

Inclusion Criteria:

Parkinson's Disease group :

Patients with Parkinson's Disease, who where included in the PRODYGI-1 cohort still meeting the MP criteria, Always followed in the service of neurology and pathology of the movement.

Pathological control group:

• Patients suffering from Richardson syndrome.
• Aged over 18

Healthy control group:

• Age-matched (± 5 years)
• Recruited on the basis of volunteering.
• free from any progressive neurological pathology after clinical examination and MoCA.

Exclusion Criteria:

For all groups:

• Pregnant or lactating woman
• Extra-neurological severe respiratory pathology
• Terminal heart failure
• Contraindication to MRI
• Refusal / withdrawal / inability to give consent
• ENT pathology.