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| ID | Type | Description | Link |
|---|---|---|---|
| 2009-A01018-49 | Other Identifier | ID-RCB number, ANSM |
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Excess weight or obesity is associated with an increased risk of health disorders: high blood pressure, diabetes, cardiovascular risks, dyslipidemia and sleep apneas. During pregnancy in obese women, the risk of preeclampsia increases by three and the risk of fetal death in utero by five. Snoring and Obstructive sleep apnea (OSA) may be associated with increased risk of adverse pregnancy outcomes, including maternal cardio pulmonary status, fetal heart rate and fetal acidosis-basis status by recurrent upper-airway obstruction, hypoventilation, and intermittent nocturnal hypoxia. Reports in pregnancy have identified in association with OSA and preeclampsia, intrauterine growth restriction and stillbirth.
The prevalence of OSA among women is estimated to be 2-5%, but it remains underdiagnosed during pregnancy. In sleep apnea syndrome, a few data have shown better pregnancy and fetal outcome with the use continuous positive airway pressure (CPAP) therapy.
the hypothesis is in obese pregnant women that there could be a significant association between sleep apnea syndrome and hypertensive disorders, preeclampsia and adverse fetal outcomes This is a prospective study of Women with a body mass index of 35 kg.m2 or greater. The aim of this study is to determinate the prevalence of sleep apnea syndrome in obese pregnant women and the benefit of CPAP on the maternal and fetal outcome.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| OSA in obese patient during pregnancy | Experimental | OSA in polysomnography |
|
| no OSA in obese patient during pregnancy | Experimental | no OSA in polysomnography |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| polysomnography | Diagnostic Test |
|
| Measure | Description | Time Frame |
|---|---|---|
| Occurrence of apnea objectified by polysomnography according to specific neurophysiological criteria | during the sleep time, an average 8 hours |
| Measure | Description | Time Frame |
|---|---|---|
| occurrence of vascular disease | High blood pressure (HTAG), Essential or chronic hypertension, preeclampsia, Severe preeclampsia | from inclusion at the beginning of the management of pregnancy to delivery |
| Evaluation of fetal impact by correlation of birth weight to gestational age |
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Inclusion Criteria:
Exclusion Criteria:
pregnancy
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| Name | Affiliation | Role |
|---|---|---|
| Anne-Frédérique Dalmas, MD | University Hospital, Lille | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| CHRU,Hôpital Jeanne de Flandre | Lille | North | 59037 | France |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 32898189 | Result | Ghesquiere L, Deruelle P, Ramdane Y, Garabedian C, Charley-Monaca C, Dalmas AF. Obstructive sleep apnea in obese pregnant women: A prospective study. PLoS One. 2020 Sep 8;15(9):e0238733. doi: 10.1371/journal.pone.0238733. eCollection 2020. |
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| ID | Term |
|---|---|
| D020181 | Sleep Apnea, Obstructive |
| D011248 | Pregnancy Complications |
| D011225 | Pre-Eclampsia |
| D009765 | Obesity |
| D012891 | Sleep Apnea Syndromes |
| ID | Term |
|---|---|
| D001049 | Apnea |
| D012120 | Respiration Disorders |
| D012140 | Respiratory Tract Diseases |
| D020919 | Sleep Disorders, Intrinsic |
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| ID | Term |
|---|---|
| D017286 | Polysomnography |
| ID | Term |
|---|---|
| D008991 | Monitoring, Physiologic |
| D019937 | Diagnostic Techniques and Procedures |
| D003933 | Diagnosis |
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| from inclusion at the beginning of the management of pregnancy to delivery |
| D020920 |
| Dyssomnias |
| D012893 | Sleep Wake Disorders |
| D009422 | Nervous System Diseases |
| D005261 | Female Urogenital Diseases and Pregnancy Complications |
| D000091642 | Urogenital Diseases |
| D046110 | Hypertension, Pregnancy-Induced |
| D050177 | Overweight |
| D044343 | Overnutrition |
| D009748 | Nutrition Disorders |
| D009750 | Nutritional and Metabolic Diseases |
| D001835 | Body Weight |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |