Main objective:

Determine the prevalence of obstructive sleep apnea syndrome (OSA) in late pregnancy in a population of obese patients .

Secondary objectives :

• Identify risk factors for OSA during pregnancy (age, parity, high blood pressure, snoring , weight, neck circumference, scores on symptoms of sleep apnea, ... ) .
• Compare perinatal morbidity among obese patients with OSA in late pregnancy with case-controls.
• Evaluate the evolution of a moderate or severe OSA 6 months after pregnancy.

Material and methods

Characteristics of the study:

• Interventional biomedical research
• Prospective Multicenter nonrandomized study

Flow chart

• Patients will be included between 30 and 36 weeks of amenorrhea (WA) .
• Will rated from inclusion: age, parity, weight, height, BMI in early pregnancy, neck circumferrence, treated high blood pressure.
• As recommended in France, the main test results during the pregnancy follow-up will be recorded.
• At the inclusion visit will be conducted a Berlin Questionnaire and Epworth Score.
• Screening for OSA by nocturnal polysomnography will be performed between 30 and 36WA. This screening can be performed as an outpatient.
• In case of proven OSA patients will be offered an appropriate care by today's standards.
• Whatever the outcome of pregnancy, a second polysomnography will be performed 6 months after childbirth in case of OSA during pregnancy.

Inclusion Criteria:

• BMI >35
• Pregnancy after 30 Weeks of amenorhea
• Age > 18
• Signed consentment
• Nationnal Health Program affiliation

Exclusion Criteria:

• Twin or more pregnancy
• Imprecise term
• Artificial insemination with donor gametes
• Proved thrombophilia
• chronic renal failure
• Previously treated (with CPAP) obstructive sleep apnea syndrom