Xenon-anesthesia on Patients Undergoing Major Liver-resection

Xenon-anesthesia on Patients Undergoing Major Liver-resection: Randomized Controlled Trial

The aim of this study is to compare the postoperative outcome of patients undergoing major liver resection under xenon- compared to desflurane-anesthesia.

The aim of this study is to compare the postoperative liver function and additional outcome parameters of patients undergoing major liver resection under xenon- compared to desflurane-anesthesia. Xenon is known to maintain hemodynamic stability and consecutive tissue perfusion. Together with its potential for ischemic pre-conditioning, we hypothesize a protective effect of xenon on post-operative liver failure and ischemia/reperfusion injury.

Inclusion Criteria:

• ≥ 3 segments liver resection
• ≥ 18 years
• Both gender
• American Society of Anesthesiologists (ASA) classification I-III
• Written informed consent prior to study participation

Exclusion Criteria:

Subjects, fulfilling one or more of the following exclusion criteria will not be included in the study:

• Severe pulmonary or airway disease
• Severe liver disease, accompanied by a Child-Pugh class >A
• Allergy/hypersensitivity to study medications
• ASA ≥ IV
• Patients susceptible to malignant hyperthermia
• Women who are pregnant, breast-feeding or women of childbearing potential not using adequate contraceptive methods
• Patients with preeclampsia or eclampsia
• Patients legally unable to give written informed consent.
• Patients with risk of high oxygen demand
• Patient with seriously impaired cardiac function
• All contraindications for xenon anesthesia according to the summary of product characteristics LENOXe
• Patient participates in a parallel interventional clinical trial during this study or receives an investigational drug within 30 days prior to inclusion into this study