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The improvement of imaging techniques in ophthalmology has made it possible to carry out a precise non-invasive study of the retinal microvascular network and to detect early abnormalities in retinal disorders. The presence of such early retinal abnormalities remains poorly known during type 1 diabetes and may be detected with OCT-angiography. Furthermore, the association with glycemic variability, likely to have deleterious effects on microvessels, has never been studied.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Patients | type 1 diabetes patients |
| |
| Healthy controls | non diabetic control subjects of the same age |
| |
| Dyslipidemic controls | non-diabetic control participants with familial dyslipidemia |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Retinal imaging assessment | Procedure |
|
| Measure | Description | Time Frame |
|---|---|---|
| surface of the central retinal avascular zone | measurement of superficial capillary plexus | inclusion |
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Inclusion Criteria:
For the patient group
Patient who has given consent
Patient who has given consent
Non-diabetic patient
For dyslipidemic control group:
Exclusion Criteria:
For the patient group
Presence of diabetic retinopathy
Protected patient:
For the healthy control group
Ophthalmological history (vascular and degenerative macular conditions)
Protected patient:
For dyslipidemic control group:
Ophthalmological history (vascular and degenerative macular conditions)
Protected patient:
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Diabetes Type 1 patients followed in the Endocrinology Department of the CHU Dijon Bourgogne or in a diabetology surgery, and non-diabetic controls will be recruited in the Ophthalmology Department of the CHU Dijon Bourgogne
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| CHU Dijon Bourgogne | Recruiting | Dijon | 21000 | France |
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| blood glucose holter | Procedure | for 40 subjects, implantation of a blood glucose holter monitor for 7 days |
|