A Study of the Efficacy and Safety of Dulaglutide (LY2189265) in Participants With Type 2 Diabetes | NCT03495102 | Trialant

A Study of the Efficacy and Safety of Dulaglutide (LY2189265) in Participants With Type 2 Diabetes | NCT03495102 | Trialant

Ages Eligible for Study: Adult (18-64)Older Adult (65+)
Sexes Eligible for Study: All
Accepts Healthy Volunteers: No
Eligibility Criteria: Inclusion Criteria:

Have type 2 diabetes mellitus (T2DM) for at least 6 months

Have been treated with stable metformin dose for at least 3 months

Have HbA1c ≥7.5% and ≤11.0% at study entry

Have body mass index (BMI) ≥25 kilograms per meter squared (kg/m^2)

Exclusion Criteria:

Have type 1 diabetes mellitus

Have used any glucagon-like peptide-1 receptor agonist (GLP-1 RA) or insulin, not including prior short term insulin use (≤14 days)

Have been taking any other medicine for diabetes (other than metformin) during the last 3 months

Have used in the last 3 months (or plan to use) prescription weight loss medications

Have disorders associated with slowed emptying of the stomach contents, or have had any stomach surgeries for the purpose of weight loss

Current participation in or intent to begin during the study an organized diet and/or exercise weight reduction program (other than the lifestyle and dietary measures for diabetes)

Have acute or chronic hepatitis, signs and symptoms of any other liver disease other than nonalcoholic fatty liver disease (NAFLD), or alanine transaminase (ALT) level >2.5 times the upper limit of the reference range, as determined by the central laboratory at study entry; participants with NAFLD are eligible for participation in this trial

Had chronic or acute pancreatitis any time prior to study entry

Have had a heart attack or stroke in the past 2 months, or have heart failure that significantly limits their physical activity

Estimated glomerular filtration rate (eGFR) <30 milliliters/minute/1.73m^2 (or lower than the country-specific threshold for discontinuing metformin therapy per local label), calculated by the Chronic Kidney Disease-Epidemiology (CKD-EPI) equation, as determined by the central laboratory at study entry and confirmed at lead-in

Have a personal or family history of medullary thyroid carcinoma or personal history of multiple endocrine neoplasia syndrome type 2

Have proliferative retinopathy or maculopathy requiring acute treatment according to the opinion of the investigator

Synexus- Chandler

Chandler, Arizona 85224, United States

Synexus/Central Arizona Medical Associates, PC

Mesa, Arizona 85206, United States

Central Phoenix Med Clinic LLC

Phoenix, Arizona 85020, United States

Arkansas Clinical Research

Little Rock, Arkansas 72205, United States

Anaheim Clinical Trials, LLC

Anaheim, California 92801, United States

Valley Research

Fresno, California 93720, United States

National Research Institute

Huntington Park, California 90255, United States

National Research Institute

Los Angeles, California 90057, United States

Catalina Research Institute, LLC

Montclair, California 91763, United States

Valley Clinical Trials, Inc.

Northridge, California 91325, United States

Pacific Research Partners, LLC

Oakland, California 94607, United States

National Research Institute

Panorama City, California 91402, United States

Sierra Clinical Research

Roseville, California 95661, United States

Artemis Institute for Clinical Research

San Diego, California 92103, United States

Care Access Research

Santa Clarita, California 91321, United States

Encompass Clinical Research

Spring Valley, California 91978, United States

University Clinical Investigators, Inc.

Tustin, California 92780, United States

Diablo Clinical Research

Walnut Creek, California 94598, United States

Chase Medical Research, LLC

Waterbury, Connecticut 06708, United States

ALL Medical Research, LLC

Cooper City, Florida 33024, United States

Clinical Research of South Florida

Coral Gables, Florida 33134, United States

Suncoast Research Group, LLC

Miami, Florida 33135, United States

New Horizon Research Center

Miami, Florida 33175, United States

Oviedo Medical Research

Oviedo, Florida 32765, United States

Urban Family Practice Associates, PC

Marietta, Georgia 30067, United States

In-Quest Medical Research, LLC- Peachtree Corners

Peachtree Corners, Georgia 30071, United States

Pacific Diabetes & Endocrine Center

Honolulu, Hawaii 96813, United States

East West Medical Institute

Honolulu, Hawaii 96814, United States

Elite Clinical Trials LLLP

Blackfoot, Idaho 83221, United States

Saltzer Medical Group. P.A.

Nampa, Idaho 83686, United States

Prairie Education and Research Cooperative

Springfield, Illinois 62711, United States

Synexus/Clinical Research Advantage

Evansville, Indiana 47714, United States

Midwest Institute for Clinical Research

Indianapolis, Indiana 46260, United States

Iderc, P.L.C.

West Des Moines, Iowa 50265, United States

InterMed, PA

Portland, Maine 04101, United States

MedStar Health Research Institute

Hyattsville, Maryland 20782, United States

NECCR PrimaCare Research, LLC

Fall River, Massachusetts 02721, United States

Aa Mrc Llc

Flint, Michigan 48504, United States

Troy Internal Medicine, PC

Troy, Michigan 48098, United States

Clinical Research Professionals

Chesterfield, Missouri 63005, United States

StudyMetrix Research, LLC

City of Saint Peters, Missouri 63303, United States

Montana Health Research

Billings, Montana 59102, United States

Glacier View Research Institute

Kalispell, Montana 59901, United States

Premier Research

Trenton, New Jersey 08611, United States

Manhattan Medical Research

New York, New York 10016, United States

Great Lakes Medical Research

Westfield, New York 14787, United States

Metrolina Internal Medicine, P.A.

Charlotte, North Carolina 28207, United States

Diabetes & Endocrinology Consultants PC

Morehead City, North Carolina 28557, United States

Aventiv Research

Columbus, Ohio 43213, United States

Intend Research

Norman, Oklahoma 73069, United States

IPS Research Company

Oklahoma City, Oklahoma 73103, United States

The Corvallis Clinic P.C.

Corvallis, Oregon 97330, United States

Summit Research Network Inc

Portland, Oregon 97210, United States

Heritage Valley Medical Group, Inc.

Beaver, Pennsylvania 15009, United States

Detweiler Family Medicine

Lansdale, Pennsylvania 19446, United States

Preferred Primary Care Physicians

Pittsburgh, Pennsylvania 15236, United States

Sudir Bansal M.D. Inc.

Warwick, Rhode Island 02886, United States

PMG Research of Charleston, LLC

Moncks Corner, South Carolina 29461, United States

Chattanooga Research and Medicine (CHARM)

Chattanooga, Tennessee 37404, United States

Dallas Diabetes Endocrine Center

Dallas, Texas 75230, United States

Southern Endocrinology and Associates PA

Mesquite, Texas 75149, United States

Consano Clinical Research

Shavano Park, Texas 78231, United States

Martin Diagnostic Clinic

Tomball, Texas 77375, United States

ClinPoint Trials, LLC

Waxahachie, Texas 75165, United States

Progressive Clinical Research

Bountiful, Utah 84010, United States

Advanced Research Institute

Ogden, Utah 84405, United States

Manassas Clinical Research Center

Manassas, Virginia 20110, United States

Clinical Research Partners, LLC

Richmond, Virginia 23235, United States

Capital Clincial Research Center

Olympia, Washington 98502, United States

Walla Walla Clinic

Walla Walla, Washington 99362, United States

Wenatchee Valley Hospital & Clinics

Wenatchee, Washington 98801, United States

Prevea Clinic, Inc

Green Bay, Wisconsin 54303, United States

Centro Medico CICEMO

Caba, Buenos Aires 1405, Argentina

CEDIC-Centro de Investigaciones Clinicas

Caba, Buenos Aires 1425, Argentina

Investigaciones Medicas IMOBA S.R.L.

Caba, Buenos Aires C1179AAB, Argentina

Centro de Investigaciones Metabólicas (CINME)

Ciudad Autonoma de Buenos Aire, Buenos Aires C1056ABJ, Argentina

Centro Medico Dr Laura Maffei Investigacion Clinica Aplicada

Ciudad Autonoma de Buenos Aire, Buenos Aires C1425AGC, Argentina

Centro de Investigacion y Prevencion Cardiovascular (CIPREC)

Ciudad Autonoma de, Buenos Aires C1119ACN, Argentina

Instituto de Investigaciones Clinicas Mar del Plata

Mar del Plata, Buenos Aires B7600FZN, Argentina

CIPADI

Godoy Cruz, Mendoza Province M5501ARP, Argentina

AXISMED SRL - Bioclinica Research Network

Buenos Aires, C1430CKE, Argentina

CENUDIAB

Ciudad Autonoma de Buenos Aire, 1408, Argentina

Centro Médico Viamonte

Ciudad Autonoma de Buenos Aire, C1120AAC, Argentina

Instituto Centenario

Ciudad Autonoma de Buenos Aire, C1204AAD, Argentina

Cemediab - Centro Médico Diabetológico Dr. Alejandro Chertkoff

Ciudad Autonoma de Buenos Aire, C1205AAO, Argentina

Mautalen Salud e Investigación - Servicio de Endocrinología

Ciudad Autonoma de Buenos Air, C1128AAF, Argentina

Instituto Medico Strusberg

Córdoba, X5000EDC, Argentina

Centro Medico Privado San Vicente Diabetes

Córdoba, X5006CBI, Argentina

Cent Priva Especiali Médicas Ambulatorias Inve Clin CEMAIC

Córdoba, X5008HHW, Argentina

Landesklinikum Korneuburg-Stockerau, Standort Stockerau

Stockerau, Lower Austria 2000, Austria

Universitätsklinikum Graz

Graz, Styria 8036, Austria

Ordination Dr. Evelyn Fließer-Görzer

Saint Stefan Ob Stainz, Styria 8511, Austria

VIVIT Institut am LKH Feldkirch

Feldkirch, Vorarlberg 6800, Austria

KA Rudolfstiftung

Vienna, 1030, Austria

Zentrum für klinische Studien Dr. Ursula Hanusch GmbH

Vienna, 1060, Austria

Bailey Clinic

Red Deer, Alberta T4N 6V7, Canada

Aggarwal and Associates Ltd

Brampton, Ontario L6T 0G1, Canada

T. Nemtean Medicine Professional Corporation

Mississauga, Ontario L4Y 2N8, Canada

Bluewater Clinical Research Group Inc

Sarnia, Ontario N7T 4X3, Canada

Stayner Medical Clinic

Stayner, Ontario L0M 1S0, Canada

Dr. Anil K. Gupta Medicine Professional Corporation

Toronto, Ontario M9V 4B4, Canada

Iatriko Palaiou Falirou, Medical Center

Palaió Fáliro, Athens 17562, Greece

Laiko General Hospital of Athens

Ampelokipoi, Attica 11527, Greece

Gen Hospital of Athens G Gennimatas

Athens, Attica 11527, Greece

G.Papanikolaou General Hospital

Eksochi, Thessaloniki 57010, Greece

Thermi Clinic

Thermi, Thessaloniki 57001, Greece

Athens Euroclinic

Athens, 11521, Greece

University General Hospital of Larissa

Larissa, 41110, Greece

AHEPA Hospital

Thessaloniki, 54636, Greece

Ippokrateio General Hospital of Thessaloniki

Thessaloniki, 54639, Greece

Euromedica - General Clinic of Thessaloniki

Thessaloniki, 54645, Greece

Studium Egeszseghaz Kft.

Kalocsa, Bács-Kiskun county 6300, Hungary

Kenezy Gyula Korhaz es Rendelointezet

Debrecen, Hajdú-Bihar 4031, Hungary

Grof Esterhazy Korhaz es Rendelointezeti Szakrendelo

Pápa, Veszprém megye 8500, Hungary

Szent Margit Rendelointezet

Budapest, 1032, Hungary

ClinDiab Kft.

Budapest, 1089, Hungary

Strazsahegy Medicina Bt.

Budapest, 1171, Hungary

TRANTOR 99 Bt.

Budapest, 1213, Hungary

Kanizsai Dorottya Korhaz

Nagykanizsa, 8800, Hungary

Zala Megyei Szent Rafael Korhaz

Zalaegerszeg, 8900, Hungary

Maccabi Diabetes Clinic, Grand Canyon, North District, Haifa

Haifa, 3299001, Israel

Linn Medical Center

Haifa, 3515209, Israel

Hadassah Medical Center

Jerusalem, 911201, Israel

Meir Medical Center

Kfar Saba, 4428164, Israel

Clalit Health Services - Shuali Clinic

Raanana, 4345204, Israel

ZIV Medical Center

Safed, 13100, Israel

Sakhnin Community Clinic, Clalit Health Services

Sakhnin, 3081000, Israel

Diabetes Medical Center (DMC)

Tel Aviv, 6148002, Israel

Tel Aviv Sourasky Medical Center

Tel Aviv, 6423906, Israel

Azienda Ospedaliera Universitaria Careggi

Florence, Florence 50134, Italy

Istituto Clinico Humanitas

Rozzano, Milano 20089, Italy

A.O.U. Senese Policlinico Santa Maria alle Scotte

Siena, SI 53100, Italy

Azienda Ospedaliera Papa Giovanni XXIII

Bergamo, 24127, Italy

Policlinico Mater Domini

Catanzaro, 88100, Italy

Fondazione Universitaria degli Studi G D'Annunzio

Chieti, 66100, Italy

Ospedale Santa Maria Goretti

Latina, 04100, Italy

Policlinico Giaccone

Palermo, 90127, Italy

Ospedale Civile Maggiore Borgo Trento

Verona, 37126, Italy

Hospital Univ. Dr. Jose Eleuterio Gonzalez

Monterrey, Nuevo León 64460, Mexico

Investigacion en Salud y Metabolismo S.C

Chihuahua City, 31217, Mexico

NZOZ ZDROWIE Osteo-Medic

Bialystok, 15-351, Poland

Poradnia Diabetologiczna SN ZOZ Lege Artis

Bialystok, 15-404, Poland

NS ZOZ Osrodek Diabetologiczny " Popula"

Bialystok, 15-445, Poland

Centrum Badan Klinicznych, PI House

Gdansk, 80-546, Poland

NZOZ Salvia s.c.

Katowice, 40-772, Poland

NZOZ Diab-Endo-Met

Krakow, 31-261, Poland

Centrum Terapii Wspolczesnej J.M. Jasnorzewska S.K.A.

Lodz, 90-242, Poland

Gabinety Terpa

Lublin, 20-333, Poland

NZOZ Przychodnia Specjalistyczna MEDICA

Lublin, 20-538, Poland

Centrum Medyczne OMEDICA

Poznan, 60-111, Poland

Praktyka Lekarska

Poznan, 61-655, Poland

Nzoz Neuro - Kard

Poznan, 61-853, Poland

NZOZ Przychodnia Specjalistyczna Henryk RudzkiAndrzej Wittek

Ruda Śląska, 41-709, Poland

Centralny Szpital Kliniczny MSW

Warsaw, 02-507, Poland

Regionalna Poradnia Diabetologiczna

Wroclaw, 50-127, Poland

Research and Cardiovascular Corp.

Ponce, PR 00717, Puerto Rico

Office: Dr. Luis Rivera Colon

San Juan, PR 00921, Puerto Rico

Clinical Research Puerto Rico, Inc.

San Juan, 00909, Puerto Rico

GCM Medical Group PSC

San Juan, 00917, Puerto Rico

S. C. Grandmed S.R.L., Str.

Oradea, Bihor County 410159, Romania

SC Gama Diamed SRL

Mangalia, Constanța County 905500, Romania

Spitalul Judetean de Urgenta Satu Mare

Satu Mare, Jud Satu-Mare 440055, Romania

CMI DNBM Dr. Pop Lavinia

Baia Mare, Maramureş 430222, Romania

Cosamext SRL

Târgu Mureş, Mureș County 540098, Romania

SC Diabmed Dr Popescu Alexandrina SRL

Ploieşti, Prahova 100163, Romania

SC Dianutrilife Medica SRL

Ploieşti, Prahova 100561, Romania

Centrul Medical Dr. Negrisanu

Timișoara, Timiș County 300456, Romania

Centrul Medical de Diagnostic si Tratament Ambulatoriu Neomed SRL

Brasov, 500283, Romania

Cabinetul Medical Nicodiab SRL

Bucharest, 010507, Romania

Easydiet SRL

Bucharest, 010627, Romania

SC Nutrilife SRL

Bucharest, 013682, Romania

SC Medcon SRL

Buzău, 120203, Romania

Centrul Medical Unirea SRL

Cluj-Napoca, 400349, Romania

Cabinet Medical Urodiamed S.R.L.

Craiova, 200349, Romania

Milena Sante SRL

Galati, 800001, Romania

SC Olimpia Med SRL

Iași, 700400, Romania

Regional Clinical Hospital

Saratov, Russian Federation 410053, Russia

Arkhangelsk Regional Clinical Hospital

Arkhangelsk, 163045, Russia

Arkhangelsk the first city clinical hospital

Arkhangelsk, 163045, Russia

Rostov State Medical University

Rostov-on-Don, 344022, Russia

City Hospital of Saint Martyr Elizabeth

Saint Petersburg, 193257, Russia

SPb GUZ "Diagnostic Center #85"

Saint Petersburg, 198255, Russia

Human care s.r.o.

Košice, Slovak Republic 04012, Slovakia

MediVet s.r.o.

Malacky, Slovak Republic 90101, Slovakia

Areteus s.r.o.

Trebišov, Slovak Republic 07501, Slovakia

Diacrin s.r.o.

Bratislava, 84102, Slovakia

Noemis, s.r.o.

Nové Mesto nad Váhom, 91501, Slovakia

FUNKYSTUFF s.r.o.

Nové Zámky, 94001, Slovakia

MUDr. Jan Culak, s.r.o.

Prievidza, 97101, Slovakia

DIA-MED CENTRUM s.r.o.

Púchov, 02001, Slovakia

Tatratrial s.r.o.

Rožňava, 04801, Slovakia

Hospital Infanta Luisa

Seville, Andalusia 41010, Spain

Clinica Juaneda

Palma de Mallorca, Balearic Islands 07014, Spain

Corporació Sanitaria Parc Tauli

Sabadell, Barcelona 08208, Spain

Hospital Universitario Marques De Valdecilla

Santander, Cantabria 39011, Spain

Hospital Universitario Quiron Madrid

Pozuelo de Alarcón, Madrid 28223, Spain

Instituto de Ciencias medicas

Alicante, 03004, Spain

Clinica San Pedro

Almería, 04001, Spain

Centre Medico Teknon

Barcelona, 08022, Spain

Hospital Clinico Universitario San Cecilio

Granada, 18012, Spain

Virgen de Las Nieves

Granada, 18014, Spain

Centro Especialidades San Jose Obrero (Barbarela)

Málaga, 29006, Spain

Clinica Nuevas Tecnologias en Diabetes y Endocrinologia

Seville, 41003, Spain

Hospital Universitario Virgen Macarena

Seville, 41009, Spain

Policlinica Galileo

Teruel, 44002, Spain

Chung Shan Medical University Hospital

Taichung, 40201, Taiwan

Taichung Veterans General Hospital

Taichung, 40705, ROC, Taiwan

Chi-Mei Medical Center

Tainan, 71004, Taiwan