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The aims of this study are to assess the performance of the non-invasive Electrical Impedance Technology (EIT) in evaluating the liver fibrosis stage in patients with chronic liver diseases, in comparisons with a liver biopsy and/or Shear wave elastography and Liver Ultrasonography.
The second aim is comparing between Liver Ultrasonography and Electrical Impedance Technology (EIT) to quantify the hepatic steatosis grade in patients with Non Alcoholic Fatty Liver Disease (NAFLD) .
The study will include 210 patients with chronic liver diseases. Relevant clinical data such as sex, age, weight, height, alcohol intake, medical history and routine lab results will be collected.
The study will include three groups:
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Biopsy: Routine tests & EIT Technology | Experimental | The patients will undergo a routine liver biopsy and also routine liver Ultrasonography, Shear wave elastography and Electrical Impedance Technology (EIT). |
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| Routine tests & EIT Technology | Experimental | The patients will undergo a routine liver Ultrasonography, Shear wave elastography and Electrical Impedance Technology (EIT). |
|
| NASH : Routine tests & EIT Technology | Experimental | The patients will undergo a routine liver Ultrasonography, Shear wave elastography and quantification of liver steatosis using the Electrical Impedance Technology (EIT). |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| EIT Technology | Device | Electrical Impedance Technology is a non-invasive imaging method who is being tested for evaluation of liver fibrosis stage |
|
| Measure | Description | Time Frame |
|---|---|---|
| Evaluating the liver fibrosis stage using Electrical Impedance Technology (EIT) | Comparing EIT fibrosis stage result to fibrosis stage result of validated thechnologies | Each technology will be performed once in 1 year |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Avishag Hassid, MA | Contact | +972-35307176 | avishag.hassid@sheba.health.gov.il | |
| Ziv Ben-Ari, MD | Contact | +972-35307176 | ziv.ben-ari@sheba.health.gov.il |
| Name | Affiliation | Role |
|---|---|---|
| Ziv Ben-Ari, MD | Sheba Medical Center | Principal Investigator |
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| ID | Term |
|---|---|
| D008103 | Liver Cirrhosis |
| D065626 | Non-alcoholic Fatty Liver Disease |
| ID | Term |
|---|---|
| D008107 | Liver Diseases |
| D004066 | Digestive System Diseases |
| D005355 | Fibrosis |
| D010335 | Pathologic Processes |
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| D013568 |
| Pathological Conditions, Signs and Symptoms |
| D005234 | Fatty Liver |