Non Invasive Assessment of Liver Fibrosis in Fatty Liver Disease

Randomized Clinical Trial to Detect Advanced Fibrosis by Non-invasive Methods in Subjects With Non-alcoholic Fatty Liver Disease

The purpose of this randomized clinical trial is to evaluate the utility of noninvasive markers for the detection of advanced fibrosis in patients newly diagnosed with Non-alcoholic Fatty Liver Disease (NAFLD) by ultrasound.

The primary objective is to determine the effectiveness of noninvasive markers for detect of advanced fibrosis in patients with diagnosis of fatty liver disease.

The secondary objectives are:

• To determine the increase in health care with the specialist (gastroenterologist or endocrinologist).
• To determine which noninvasive evaluation strategy favors any treatment of fatty liver disease.

Inclusion Criteria:

• Patients with BMI ≥ 27 Kg/m2 and any stage of non alcoholic fatty liver, diagnosed by ultrasound.

Exclusion Criteria:

• Patients with other liver disease.
• Patients under treatment with tamoxifen, methotrexate, amiodarone, diltiazem or other drugs able to induce fatty liver.
• Patients with alcohol consumption greater than 140 gr. per week
• Patients who have received blood transfusion before 1990