Comparison of Single Intra-articular Injection of Hyruan-One With Hylan G-F 20 in Knee Osteoarthritis

Comparison of Single Intra-articular Injection of Hyruan-One With Hylan G-F 20 in Knee Osteoarthritis: A Randomized Double-blind, Saline-controlled Trial

We compare the efficacy of intra-articular injection of Hyruan-One with Hylan G-F 20 and placebo (NSS) controlled in a double-blind RCT.

Inclusion Criteria:

• Symptomatic primary knee osteoarthritis with failed conservative treatment for at least 3 months
• Gave informed consent
• Can do questionnaires

Exclusion Criteria:

• Severe deformity (varus or valgus from a mechanical axis more than 10 degrees
• Allergy to hyaluronic acid
• Pain in the hip or ankle
• Post-traumatic or post surgery of lower extremity
• Post-infection of the knee
• Previous hyaluronic acid injection within 6 months
• Pregnancy or lactation
• Underlying Rheumatoid arthritis, stroke, malignancy, venous occlusion