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Corticosteroid and Hylan G-F 20 are both effective in improving pain and function of osteoarthritic knee patients.
Corticosteroid and Hylan G-F 20 are both effective in improving pain and function of osteoarthritic knee patients up to 6 months.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Single shot Hylan G-F 20 (Synvisc) | Experimental | Intra-articular injection of the Single shot 6 mL of Hylan G-F 20 (Synvisc) |
|
| Corticosteroid (Triamcinolone acetonide) | Active Comparator | Intra-articular injection of 1 mL of 40 mg Triamcinolone acetonide plus 5 mL of 1% xylocaine with adrenaline injected at the knee by single shot |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Hylan G-F 20 | Drug | After full aseptic preparation, Single shot intra-articular injection either 6 mL of Hylan G-F 20 or 1 mL of 40 mg triamcinolone acetonide plus 5 mL of 1% xylocaine with adrenaline were injected into the joint cavity using the infero-lateral approach via a 21-gauge needle. |
| Measure | Description | Time Frame |
|---|---|---|
| WOMAC Score | Change from Baseline in WOMAC score at 6 months | 6 months |
| Measure | Description | Time Frame |
|---|---|---|
| Visual Analogue Scale(VAS) | Change from Baseline in VAS score at 6 months | 6 months |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Nattapol Tammachote, MD, MSc | Department of Orthopaedics, Thammasat University | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Thammasat University Hospital, Thammasat University | Prathumthani | Changwat Pathum Thani | 12121 | Thailand |
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| ID | Term |
|---|---|
| D020370 | Osteoarthritis, Knee |
| ID | Term |
|---|---|
| D010003 | Osteoarthritis |
| D001168 | Arthritis |
| D007592 | Joint Diseases |
| D009140 | Musculoskeletal Diseases |
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| ID | Term |
|---|---|
| C049816 | hylan |
| D000305 | Adrenal Cortex Hormones |
| D014222 | Triamcinolone Acetonide |
| ID | Term |
|---|---|
| D006728 | Hormones |
| D006730 | Hormones, Hormone Substitutes, and Hormone Antagonists |
| D014221 | Triamcinolone |
| D011245 | Pregnadienes |
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|
| Corticosteroid | Drug | After full aseptic preparation, Single shot intra-articular injection either 6 mL of Hylan G-F 20 or 1 mL of 40 mg triamcinolone acetonide plus 5 mL of 1% xylocaine with adrenaline were injected into the joint cavity using the infero-lateral approach via a 21-gauge needle. |
|
|
| D012216 |
| Rheumatic Diseases |
| D011278 | Pregnanes |
| D013256 | Steroids |
| D000072473 | Fused-Ring Compounds |
| D011083 | Polycyclic Compounds |
| D013259 | Steroids, Fluorinated |