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| ID | Type | Description | Link |
|---|---|---|---|
| 2018-A00405-50 | Other Identifier | ID-RCB |
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Effective exploration of the environment, check for information to improve one's own performance, are fundamental abilities of human cognition. These abilities are dependent on the process of cognitive control.
However, they are clearly impaired and uncontrollable in certain behavioral disorders such as obsessive-compulsive disorder (OCD). Compulsive checks of these patients, spontaneously associated with a feeling of intense uncertainty, suggest disturbances of evaluative and metacognitive functions. However, no biological observations have yet been able to feed these hypotheses.
The evaluation of decisions and actions involves the middle cingulate cortex (MCC) (which belongs to a cortico-subcortical network structurally and functionally altered in OCD patients). Cingulotomy has long been used as a therapy in severe OCD, with However, the precise part of the cingulate cortex that contributes to check (and its pathological forms) remains to be discovered.
The purpose of this research campaign is to determine, through functional magnetic resonance imaging (fMRI) and electroencephalography (EEG) in healthy human subjects:
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| fMRI and EEG study | Experimental |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| fMRI and EEG study | Other | fMRI and EEG study |
|
| Measure | Description | Time Frame |
|---|---|---|
| Measuring changes in brain activity in regions of interest when performing cognitive tasks. | Behavior: Measurement of reaction times of correct answer during cognitive task. fMRI and EEG: Brain activity signal, | through study completion, an average of 3 years |
| Measuring changes in brain activity in regions of interest when performing cognitive tasks. | Behavior: Measurement of % of correct answer during cognitive task. | through study completion, an average of 3 years |
| Measuring changes in brain activity in regions of interest when performing cognitive tasks. | - Measurement of the amplitude of the BOLD signal change in MRI according to the different cognitive tasks in the different regions of interest. Measurement of resting GABA and Glutamate concentrations in the different regions of interest. Measurement of the amplitude of the change of the electrical signal in EEG according to the different cognitive tasks in the different regions of interest. | through study completion, an average of 3 years |
| Measure | Description | Time Frame |
|---|---|---|
| Calculation of the correlations in the regions of interest of the individual values of the Blood Oxygen Level Dependent (BOLD) signal with the data of the concentration of Acide γ-aminobutyrique (GABA) | calculate with the bold signal (spectroscopy) | through study completion, an average of 3 years |
| Calculation of the correlations in the regions of interest of the individual values of the Blood Oxygen Level Dependent (BOLD) signal with the data of the amplitude of the electrical signal (EEG) |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Emmanuel Procyk | INSERM U1208 | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Inserm U1208 | Bron | France |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 27319361 | Result | Stoll FM, Fontanier V, Procyk E. Specific frontal neural dynamics contribute to decisions to check. Nat Commun. 2016 Jun 20;7:11990. doi: 10.1038/ncomms11990. |
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| through study completion, an average of 3 years |