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This study, a case-control study, aims to investigate the function-metabolism coupling in decision-making confidence neural network of obsessive-compulsive disorder.
OCD shows various abnormalities in cognitive function. Decision-making confidence is a burgeoning research focus on cognitive abnormality of OCD. Gamma-aminobutyric acid (GABA) is a type of inhibitory amino acid. Some studies have indicated that GABA shows metabolic abnormality in OCD.
Repetitive transcranial magnetic stimulation (rTMS) is a safe and noninvasive treatment for OCD. This study intends to explore the differences of the function-metabolism coupling in decision-making confidence neural network between OCD and HC. And investigating the dynamic changes of the function-metabolism coupling after rTMS treatment (6 weeks) for OCD is another goal.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| OCD group | Active Comparator | OCD patients will receive rTMS treatment for 6 weeks. |
|
| HC group | No Intervention | Health control will not receive any treatment. |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Repetitive transcranial magnetic stimulation | Device | The OCD group will receive rTMS treatment for 6 weeks. There are 5 rTMS treatments per week (Monday to Friday), and 30 rTMS treatments in total. Treatment is administered by Ma GPro X100 device (Maga Venture) with Cool-DB80 coil. Detailed parameters of rTMS: intensity of stimulus is 120% RMT; the frequency of trains is 1Hz and the number of pulses is 1; no intertrain intervals and the pulses number is 1000. |
| Measure | Description | Time Frame |
|---|---|---|
| Yale-Brown Obsessive-Compulsive Scale (YBOCS) | YBOCS is compiled by Goodman in the United States and contains 10 items to assess the severity of obsessive thoughts and compulsive behavior. The scoring method adopts a five-point scale of 0-4 points, and the total score range is 0-40 points, which has good reliability and validity. | Change from Baseline at 6weeks |
| Measure | Description | Time Frame |
|---|---|---|
| Hamilton Depression Scale (HAMD-17) | It is one of the most widely used examiner-rating depression scales, which contains 17 items. It is used to measure the severity of depression and its change in treatment. The total score range is 0-59, and a lower score means a better outcome. | Change from Baseline at 6weeks |
| Measure | Description | Time Frame |
|---|---|---|
| Decision-making confidence | The decision-making confidence is measure by randomized dot motion (RDM) task with a self-reported confidence scale (1-4 points). And a lower score means a lower decision-making confidence. | Change from Baseline at 6weeks |
| The distribution and level of GABA in the brain |
Inclusion Criteria:
OCD group:
HC group:
Exclusion Criteria:
OCD group:
HC group:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Qihui Guo | Contact | 15221398831 | guoharry@qq.com |
| Name | Affiliation | Role |
|---|---|---|
| Qing Fan, Doctor | Shanghai Mental Health Center | Study Chair |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Shanghai Mental Health Center | Shanghai | Shanghai Municipality | 200030 | China |
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| ID | Term |
|---|---|
| D009771 | Obsessive-Compulsive Disorder |
| ID | Term |
|---|---|
| D001008 | Anxiety Disorders |
| D001523 | Mental Disorders |
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| ID | Term |
|---|---|
| D050781 | Transcranial Magnetic Stimulation |
| ID | Term |
|---|---|
| D055909 | Magnetic Field Therapy |
| D013812 | Therapeutics |
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|
| Hamilton Anxiety Scale (HAMA-14) |
It is one of the most widely used examiner-rating anxiety scales, which contains 14 items. It is used to measure the severity of anxiety and its change in treatment. The scoring method adopts a five-point scale of 0-4 points. The total score range is 0-56 and a lower score means a better outcome. |
| Change from Baseline at 6weeks |
| Florida Obsessive Compulsive Inventory (FOCI) | FOCI, a self-rating scale, is used to assess the severity of obsessive-compulsive symptoms within one month, which contains 20 items. The first 15 items are evaluated the symptoms by yes and no, and the last 5 items are evaluated the severity of symptoms on 0-4 five-point scale. The total score range is 0-20 and a lower score means a better outcome. | Change from Baseline at 6weeks |
| Obsessive Belief Questionnaire (OBQ-44) | It is a self-rating scale to assess the severity of the obsessive belief, which contains 44 items. The scoring method adopts a seven-point scale of 1-7 points. The total score range is 44-308 and a lower score means a better outcome. | Change from Baseline at 6weeks |
| State-Trait Anxiety Inventory (STAI) | It is one of the most widely used self-rating anxiety scales, which contains 40 items. The first 20 items are used to measure the state anxiety and the last 20 items are used to measure trait anxiety. The scoring method adopts a four-point scale of 1-4 points. Both the total score range of state anxiety and trait anxiety are 20-80 and a lower score means a better outcome. | Change from Baseline at 6weeks |
Using the SPICE (an advanced MRI technology) to measure the distribution and level of gamma-aminobutyric acid (GABA) in the brain. The change of GABA metabolism will be observed during treatment. |
| Change from Baseline at 6weeks |