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This is a prospective study of children <21 years of age with the goal of characterizing the PK of drugs administered per standard of care as prescribed by the treating caregiver.
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Standard of care drug | Drug | This study is collecting PK data on children prescribed the following drugs of interest per standard of care: dexmedetomidine, bosentan, furosemide, chlorothiazide, ethacrynic acid, bumetanide, hydromorphone, tacrolimus, ampicillin, gentamicin, caffeine, fentanyl, midazolam, foscarnet, hydroxychloroquine, and moxifloxacin. |
| Measure | Description | Time Frame |
|---|---|---|
| Area under the curve (AUC) | Data will be collected throughout the hospital or outpatient stay up to 90 days |
| Measure | Description | Time Frame |
|---|---|---|
| Maximum concentration (Cmax) | Data will be collected throughout the hospital or outpatient stay up to 90 days | |
| Time to achieve maximum concentration (Tmax) | Data will be collected throughout the hospital or outpatient stay up to 90 days |
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Inclusion Criteria:
Exclusion Criteria:
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Children (<21 years of age) receiving drugs per standard of care as prescribed by treating caregiver
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Rachel G Greenberg, MD | Contact | 9196684725 | rachel.greenberg@duke.edu |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Duke University | Recruiting | Durham | North Carolina | 27710 | United States |
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| ID | Term |
|---|---|
| D054198 | Precursor Cell Lymphoblastic Leukemia-Lymphoma |
| ID | Term |
|---|---|
| D007945 | Leukemia, Lymphoid |
| D007938 | Leukemia |
| D009370 | Neoplasms by Histologic Type |
| D009369 | Neoplasms |
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| Absorption rate constant (ka) | Data will be collected throughout the hospital or outpatient stay up to 90 days |
| Elimination rate constant (kel) | Data will be collected throughout the hospital or outpatient stay up to 90 days |
| Half-life (t1/2) | Data will be collected throughout the hospital or outpatient stay up to 90 days |
| D006402 |
| Hematologic Diseases |
| D006425 | Hemic and Lymphatic Diseases |
| D008232 | Lymphoproliferative Disorders |
| D008206 | Lymphatic Diseases |
| D007160 | Immunoproliferative Disorders |
| D007154 | Immune System Diseases |