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| ID | Type | Description | Link |
|---|---|---|---|
| IND 113645 | Other Identifier | FDA | |
| IND 114369 | Other Identifier | FDA | |
| IND 114531 | Other Identifier | FDA | |
| IND 118358 | Other Identifier | FDA | |
| HHSN20100006 | Other Grant/Funding Number | NICHD | |
| HHSN27500020 | Other Grant/Funding Number | NICHD | |
| HHSN27500027 | Other Grant/Funding Number | NICHD | |
| HHSN27500043 | Other Grant/Funding Number | NICHD | |
| HHSN27500049 | Other Grant/Funding Number | NICHD |
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| Name | Class |
|---|---|
| Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) | NIH |
| The Emmes Company, LLC | INDUSTRY |
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Understudied drugs will be administered to children per standard of care as prescribed by their treating caregiver and only biological sample collection during the time of drug administration will be involved. A total of approximately 7000 children aged <21 years who are receiving these drugs for standard of care will be enrolled and will be followed for up a maximum of 90 days. The goal of this study is to characterize the pharmacokinetics of understudied drugs for which specific dosing recommendations and safety data are lacking. The prescribing of drugs to children will not be part of this protocol. Taking advantage of procedures done as part of routine medical care (i.e. blood draws) this study will serve as a tool to better understand drug exposure in children receiving these drugs per standard of care. The data collected through this initiative will also provide valuable pharmacokinetic and dosing information of drugs in different pediatric age groups as well as special pediatric populations (i.e. obese).
The purpose of this study is to characterize the PK ( Pharmacokinetics) of understudied drugs administered to children per standard of care as prescribed by their treating caregiver. This will be accomplished by the collection of biological samples during the time of drug administration per standard of care as prescribed by the caregiver. The prescribing of drugs to children will not be part of this protocol.
Aim #1: Evaluate the PK of understudied drugs currently being administered to children.
Hypothesis #1: The PK of understudied drugs in children will differ from adults and within children according to pediatric age groups or special population.
Aim #2: Explore the pharmacodynamics (PD) of understudied drugs currently being administered to children.
Hypothesis #2: The PD of targeted drugs in children will differ from adults.
Aim #3: Evaluate the influence of genetic factors, metabolic and protein profiles on therapeutic exposure.
Hypothesis #3: Genetic polymorphisms in drug metabolizing enzymes and metabolic and proteomic profiles will impact drug exposure in children.
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| The POPS study is collecting PK data on children prescribed the following drugs of interest per standard of care: | Drug |
|
| Measure | Description | Time Frame |
|---|---|---|
| Composite of pharmacokinetic outcomes for understudied drugs in children | As appropriate for each study drug, the following additional PK parameters will be estimated:
Penetration into body fluids will be determined by comparing exposure (i.e. AUC, Cmax) ratios between the body fluid and plasma or comparison of concentrations in paired samples. | Data will be collected throughout the hospital or outpatient stay up to 90 days |
| Measure | Description | Time Frame |
|---|---|---|
| Composite pharmacodynamic outcomes of understudied drugs in children | When applicable, Monte Carlo simulations will be performed to evaluate therapeutic target attainment rates (pharmacodynamics) in the population of interest. The final PK model and parameters estimated in the population PK analysis will be used to perform these simulations. | Data will be collected throughout the hospital or outpatient stay up to 90 days |
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Inclusion Criteria:
Exclusion Criteria:
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Children (<21 years of age) receiving drugs per standard of care as prescribed by treating caregiver
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| Name | Affiliation | Role |
|---|---|---|
| Chi Hornik, PharmD | Duke University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Alaska Native Medical Center | Anchorage | Alaska | 99508 | United States | ||
| Arkansas Children's Hospital |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 24614374 | Result | Tremoulet A, Le J, Poindexter B, Sullivan JE, Laughon M, Delmore P, Salgado A, Ian-U Chong S, Melloni C, Gao J, Benjamin DK Jr, Capparelli EV, Cohen-Wolkowiez M; Administrative Core Committee of the Best Pharmaceuticals for Children Act-Pediatric Trials Network. Characterization of the population pharmacokinetics of ampicillin in neonates using an opportunistic study design. Antimicrob Agents Chemother. 2014 Jun;58(6):3013-20. doi: 10.1128/AAC.02374-13. Epub 2014 Mar 10. | |
| 24949994 |
| Label | URL |
|---|---|
| Understudied Drugs Project Summary | View source |
Not provided
Completed study datasets (limited PHI) may be requested from https://pediatrictrials.org/data-sharing-opportunities Study data may be posted to the NICHD Data and Specimen Hub (DASH)
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whole blood
| Biomarkers associated with understudied drugs in children | The dosing, sampling, and demographic information recorded on the electronic data collection forms will be merged with the bioanalytical information to create a biomarker dataset for each study drug. Biomarkers will be identified using metabolomics/proteomics and pharmacogenomics methodologies. Samples for biomarker analysis will be stored for future use in a PTN designated biorepository. Associations between biomarkers and drug exposure will be explored by visual inspection (i.e. scatter plots) and statistical comparisons as needed. | Data will be collected throughout the hospital or outpatient stay up to 90 days |
| Little Rock |
| Arkansas |
| 72202 |
| United States |
| University of California at San Diego Medical Center | La Jolla | California | 92093 | United States |
| Axis Clinical Trials | Los Angeles | California | 90036 | United States |
| University of California, Los Angeles Medical Center | Los Angeles | California | 90095 | United States |
| The Children's Hospital Colorado | Aurora | Colorado | 80045 | United States |
| Yale New Haven Children's Hospital | New Haven | Connecticut | 06504 | United States |
| Alfred I. DuPont Hospital for Children | Wilmington | Delaware | 19803 | United States |
| Children's National Medical Center | Washington D.C. | District of Columbia | 20010 | United States |
| University of Florida Jacksonville Shands Medical Center | Jacksonville | Florida | 32209 | United States |
| Kapiolani Womens and Childrens Medical Center | Honolulu | Hawaii | 96826 | United States |
| Lurie Children's Hospital of Chicago | Chicago | Illinois | 60614 | United States |
| Riley Hospital for Children at Indiana University | Indianapolis | Indiana | 46202 | United States |
| University of Kansas Medical Center | Fairway | Kansas | 66205 | United States |
| Children's Mercy Hospital and Clinics | Kansas City | Kansas | 66160 | United States |
| Wesley Medical Center | Wichita | Kansas | 67214 | United States |
| Norton Children's Hospital | Louisville | Kentucky | 40202 | United States |
| Tulane University Health Science Center | New Orleans | Louisiana | 70112 | United States |
| Ochsner Baptist Clinical Trials Unit | New Orleans | Louisiana | 70115-6969 | United States |
| University of Maryland | Baltimore | Maryland | 21201 | United States |
| Children's Hospital of Michigan | Detroit | Michigan | 48201 | United States |
| University of Mississippi Medical Center | Jackson | Mississippi | 39216 | United States |
| Children's Mercy Hospitals and Clinics | Kansas City | Missouri | 64108 | United States |
| University of Montana | Missoula | Montana | 59804 | United States |
| University of Nebraska Medical Center | Omaha | Nebraska | 68198 | United States |
| Dartmouth-Hitchcock Medical Center | Lebanon | New Hampshire | 03756 | United States |
| University of New Mexico, Health Sciences Center | Albuquerque | New Mexico | 87131 | United States |
| UNC Hospital Neonatal-Perinatal Medicine | Chapel Hill | North Carolina | 27599 | United States |
| Duke University Medical Center (PICU / NICU) | Durham | North Carolina | 27710 | United States |
| Cincinnati Childrens Hospital Medical Center | Cincinnati | Ohio | 45229-3039 | United States |
| Rainbow Babies and Children's Hospital | Cleveland | Ohio | 44106 | United States |
| Akron Children's Hospital | Cleveland | Ohio | 44313 | United States |
| Board of Regents of the University of Oklahoma | Oklahoma City | Oklahoma | 73104 | United States |
| Oregon Health and Science University | Portland | Oregon | 97201-2701 | United States |
| Rhode Island Hospital | Providence | Rhode Island | 02903 | United States |
| Medical University of South Carolina | Charleston | South Carolina | 29425 | United States |
| University of South Carolina | Columbia | South Carolina | 29203 | United States |
| University of Utah Hospitals and Clinics | Salt Lake City | Utah | 84108 | United States |
| University of Vermont Medical Center | Burlington | Vermont | 05405 | United States |
| University of Virginia Children's Hospital | Charlottesville | Virginia | 22908-0386 | United States |
| Seattle Children's Hospital | Seattle | Washington | 98105 | United States |
| West Virginia University Hospital | Morgantown | West Virginia | 26506 | United States |
| Medical College of Wisconsin | Milwaukee | Wisconsin | 53226 | United States |
| Manitoba Institute of Child Health | Winnipeg | Manitoba | R3E 3P4 | Canada |
| Children's Hospital of Eastern Ontario | Ottawa | Ontario | K1H 8L1 | Canada |
| The Hospital for Sick Children | Toronto | Ontario | M5G 1X8 | Canada |
| Hospital Sainte-Justine | Montreal | Quebec | T3T 1C5 | Canada |
| Assaf Harofeh Medical Center | Zerifin | Tel Aviv | 70300 | Israel |
| Schneider Children's Medical Center of Israel | Petah Tikva | 49202 | Israel |
| KK Women's and Children's Hospital Pte Ltd | Singapore | 229899 | Singapore |
| Southampton General Hospital | Southampton | Hampshire | SO16 6YD | United Kingdom |
| Alder Hey Children's Hospital | Liverpool | Merseyside | L12 2AP | United Kingdom |
| Result |
| Gonzalez D, Melloni C, Yogev R, Poindexter BB, Mendley SR, Delmore P, Sullivan JE, Autmizguine J, Lewandowski A, Harper B, Watt KM, Lewis KC, Capparelli EV, Benjamin DK Jr, Cohen-Wolkowiez M; Best Pharmaceuticals for Children Act - Pediatric Trials Network Administrative Core Committee. Use of opportunistic clinical data and a population pharmacokinetic model to support dosing of clindamycin for premature infants to adolescents. Clin Pharmacol Ther. 2014 Oct;96(4):429-37. doi: 10.1038/clpt.2014.134. Epub 2014 Jun 20. |
| 26039810 | Result | Gonzalez D, Melloni C, Poindexter BB, Yogev R, Atz AM, Sullivan JE, Mendley SR, Delmore P, Delinsky A, Zimmerman K, Lewandowski A, Harper B, Lewis KC, Benjamin DK Jr, Cohen-Wolkowiez M; Best Pharmaceuticals for Children Act--Pediatric Trials Network Administrative Core Committee. Simultaneous determination of trimethoprim and sulfamethoxazole in dried plasma and urine spots. Bioanalysis. 2015;7(9):1137-49. doi: 10.4155/bio.15.38. |
| 27522443 | Result | Hornik CP, Benjamin DK Jr, Smith PB, Pencina MJ, Tremoulet AH, Capparelli EV, Ericson JE, Clark RH, Cohen-Wolkowiez M; Best Pharmaceuticals for Children Act-Pediatric Trials Network. Electronic Health Records and Pharmacokinetic Modeling to Assess the Relationship between Ampicillin Exposure and Seizure Risk in Neonates. J Pediatr. 2016 Nov;178:125-129.e1. doi: 10.1016/j.jpeds.2016.07.011. Epub 2016 Aug 10. |
| 26926644 | Result | Gonzalez D, Delmore P, Bloom BT, Cotten CM, Poindexter BB, McGowan E, Shattuck K, Bradford KK, Smith PB, Cohen-Wolkowiez M, Morris M, Yin W, Benjamin DK Jr, Laughon MM. Clindamycin Pharmacokinetics and Safety in Preterm and Term Infants. Antimicrob Agents Chemother. 2016 Apr 22;60(5):2888-94. doi: 10.1128/AAC.03086-15. Print 2016 May. |
| 29084742 | Result | Autmizguine J, Melloni C, Hornik CP, Dallefeld S, Harper B, Yogev R, Sullivan JE, Atz AM, Al-Uzri A, Mendley S, Poindexter B, Mitchell J, Lewandowski A, Delmore P, Cohen-Wolkowiez M, Gonzalez D; the Pediatric Trials Network Steering Committee. Population Pharmacokinetics of Trimethoprim-Sulfamethoxazole in Infants and Children. Antimicrob Agents Chemother. 2017 Dec 21;62(1):e01813-17. doi: 10.1128/AAC.01813-17. Print 2018 Jan. |
| 29271816 | Result | Le J, Poindexter B, Sullivan JE, Laughon M, Delmore P, Blackford M, Yogev R, James LP, Melloni C, Harper B, Mitchell J, Benjamin DK Jr, Boakye-Agyeman F, Cohen-Wolkowiez M. Comparative Analysis of Ampicillin Plasma and Dried Blood Spot Pharmacokinetics in Neonates. Ther Drug Monit. 2018 Feb;40(1):103-108. doi: 10.1097/FTD.0000000000000466. |
| 29435949 | Result | Dallefeld SH, Atz AM, Yogev R, Sullivan JE, Al-Uzri A, Mendley SR, Laughon M, Hornik CP, Melloni C, Harper B, Lewandowski A, Mitchell J, Wu H, Green TP, Cohen-Wolkowiez M. A pharmacokinetic model for amiodarone in infants developed from an opportunistic sampling trial and published literature data. J Pharmacokinet Pharmacodyn. 2018 Jun;45(3):419-430. doi: 10.1007/s10928-018-9576-y. Epub 2018 Feb 12. |
| 29677389 | Result | Hornik CP, Gonzalez D, van den Anker J, Atz AM, Yogev R, Poindexter BB, Ng KC, Delmore P, Harper BL, Melloni C, Lewandowski A, Gelber C, Cohen-Wolkowiez M, Lee JH; Pediatric Trial Network Steering Committee. Population Pharmacokinetics of Intramuscular and Intravenous Ketamine in Children. J Clin Pharmacol. 2018 Aug;58(8):1092-1104. doi: 10.1002/jcph.1116. Epub 2018 Apr 20. |
| 30790601 | Result | Drolet BA, Boakye-Agyeman F, Harper B, Holland K, Lewandowski A, Stefanko N, Melloni C; Pediatric Trials Network Steering Committee (See Acknowledgments for a listing of committee members.). Systemic timolol exposure following topical application to infantile hemangiomas. J Am Acad Dermatol. 2020 Mar;82(3):733-736. doi: 10.1016/j.jaad.2019.02.029. Epub 2019 Feb 18. No abstract available. |
| 31317556 | Result | Hornik CP, Yogev R, Mourani PM, Watt KM, Sullivan JE, Atz AM, Speicher D, Al-Uzri A, Adu-Darko M, Payne EH, Gelber CE, Lin S, Harper B, Melloni C, Cohen-Wolkowiez M, Gonzalez D; Best Pharmaceuticals for Children Act-Pediatric Trials Network Steering Committee. Population Pharmacokinetics of Milrinone in Infants, Children, and Adolescents. J Clin Pharmacol. 2019 Dec;59(12):1606-1619. doi: 10.1002/jcph.1499. Epub 2019 Jul 17. |
| 28779462 | Result | Maharaj AR, Gonzalez D, Cohen-Wolkowiez M, Hornik CP, Edginton AN. Improving Pediatric Protein Binding Estimates: An Evaluation of alpha1-Acid Glycoprotein Maturation in Healthy and Infected Subjects. Clin Pharmacokinet. 2018 May;57(5):577-589. doi: 10.1007/s40262-017-0576-7. |
| 31814149 | Result | Maharaj AR, Wu H, Zimmerman KO, Speicher DG, Sullivan JE, Watt K, Al-Uzri A, Payne EH, Erinjeri J, Lin S, Harper B, Melloni C, Hornik CP; Best Pharmaceuticals for Children Act - Pediatric Trials Network Steering Committee. Dosing of Continuous Fentanyl Infusions in Obese Children: A Population Pharmacokinetic Analysis. J Clin Pharmacol. 2020 May;60(5):636-647. doi: 10.1002/jcph.1562. Epub 2019 Dec 8. |
| 31548185 | Result | Thompson EJ, Wu H, Melloni C, Balevic S, Sullivan JE, Laughon M, Clark KM, Kalra R, Mendley S, Payne EH, Erinjeri J, Gelber CE, Harper B, Cohen-Wolkowiez M, Hornik CP; Best Pharmaceuticals for Children Act - Pediatric Trials Network Steering Committee. Population Pharmacokinetics of Doxycycline in Children. Antimicrob Agents Chemother. 2019 Sep 9;63(12):e01508-19. doi: 10.1128/AAC.01508-19. Epub 2019 Sep 23. |
| 32324313 | Result | Ge S, Mendley SR, Gerhart JG, Melloni C, Hornik CP, Sullivan JE, Atz A, Delmore P, Tremoulet A, Harper B, Payne E, Lin S, Erinjeri J, Cohen-Wolkowiez M, Gonzalez D; Best Pharmaceuticals for Children Act - Pediatric Trials Network Steering Committee. Population Pharmacokinetics of Metoclopramide in Infants, Children, and Adolescents. Clin Transl Sci. 2020 Nov;13(6):1189-1198. doi: 10.1111/cts.12803. Epub 2020 May 27. |
| 32497307 | Result | Maharaj AR, Wu H, Zimmerman KO, Autmizguine J, Kalra R, Al-Uzri A, Sherwin CMT, Goldstein SL, Watt K, Erinjeri J, Payne EH, Cohen-Wolkowiez M, Hornik CP. Population pharmacokinetics of olanzapine in children. Br J Clin Pharmacol. 2021 Feb;87(2):542-554. doi: 10.1111/bcp.14414. Epub 2020 Jul 5. |
| 33029806 | Result | Commander SJ, Wu H, Boakye-Agyeman F, Melloni C, Hornik CD, Zimmerman K, Al-Uzri A, Mendley SR, Harper B, Cohen-Wolkowiez M, Hornik CP; Best Pharmaceuticals for Children Act-Pediatric Trials Network Steering Committee. Pharmacokinetics of Hydrochlorothiazide in Children: A Potential Surrogate for Renal Secretion Maturation. J Clin Pharmacol. 2021 Mar;61(3):368-377. doi: 10.1002/jcph.1739. Epub 2020 Oct 7. |
| 33903114 | Result | Wu YSS, Cohen-Wolkowiez M, Hornik CP, Gerhart JG, Autmizguine J, Cobbaert M, Gonzalez D; Best Pharmaceuticals for Children Act-Pediatric Trials Network Steering Committee. External Evaluation of Two Pediatric Population Pharmacokinetics Models of Oral Trimethoprim and Sulfamethoxazole. Antimicrob Agents Chemother. 2021 Jun 17;65(7):e0214920. doi: 10.1128/AAC.02149-20. Epub 2021 Jun 17. |
| 34302290 | Result | Maharaj AR, Wu H, Zimmerman KO, Muller WJ, Sullivan JE, Sherwin CMT, Autmizguine J, Rathore MH, Hornik CD, Al-Uzri A, Payne EH, Benjamin DK Jr, Hornik CP; Best Pharmaceuticals for Children Act-Pediatric Trials Network Steering Committee. Pharmacokinetics of Ceftazidime in Children and Adolescents with Obesity. Paediatr Drugs. 2021 Sep;23(5):499-513. doi: 10.1007/s40272-021-00460-4. Epub 2021 Jul 23. |
| 35491971 | Result | Gerhart JG, Carreno FO, Ford JL, Edginton AN, Perrin EM, Watt KM, Muller WJ, Atz AM, Al-Uzri A, Delmore P, Gonzalez D; Best Pharmaceuticals for Children Act-Pediatric Trials Network Steering Committee. Use of physiologically-based pharmacokinetic modeling to inform dosing of the opioid analgesics fentanyl and methadone in children with obesity. CPT Pharmacometrics Syst Pharmacol. 2022 Jun;11(6):778-791. doi: 10.1002/psp4.12793. Epub 2022 May 2. |
| 35370711 | Result | Karatza E, Ganguly S, Hornik CD, Muller WJ, Al-Uzri A, James L, Balevic SJ, Gonzalez D. External Evaluation of Risperidone Population Pharmacokinetic Models Using Opportunistic Pediatric Data. Front Pharmacol. 2022 Mar 17;13:817276. doi: 10.3389/fphar.2022.817276. eCollection 2022. |
| 28137820 | Result | Smith MJ, Gonzalez D, Goldman JL, Yogev R, Sullivan JE, Reed MD, Anand R, Martz K, Berezny K, Benjamin DK Jr, Smith PB, Cohen-Wolkowiez M, Watt K; Best Pharmaceuticals for Children Act-Pediatric Trials Network Steering Committee. Pharmacokinetics of Clindamycin in Obese and Nonobese Children. Antimicrob Agents Chemother. 2017 Mar 24;61(4):e02014-16. doi: 10.1128/AAC.02014-16. Print 2017 Apr. |
| 41247430 | Derived | Sinha J, Zimmerman K, Balevic SJ, Hornik C, Muller WJ, Rathore M, Meyer M, Finkelstein Y, Al-Uzri A, Lakhotia A, Goldstein S, Chen JY, Anand R, Gonzalez D; Best Pharmaceuticals for Children Act-Pediatric Trials Network Steering Committee. Population Pharmacokinetic Modeling of Oxcarbazepine and Its Active Metabolite 10-Monohydroxy Derivative to Inform Dosing in Children with Obesity. Clin Pharmacokinet. 2026 Feb;65(2):329-344. doi: 10.1007/s40262-025-01579-0. Epub 2025 Nov 17. |
| 28290120 | Derived | Hornik CP, Wu H, Edginton AN, Watt K, Cohen-Wolkowiez M, Gonzalez D. Development of a Pediatric Physiologically-Based Pharmacokinetic Model of Clindamycin Using Opportunistic Pharmacokinetic Data. Clin Pharmacokinet. 2017 Nov;56(11):1343-1353. doi: 10.1007/s40262-017-0525-5. |
| ID | Term |
|---|---|
| D000257 | Adenoviridae Infections |
| D001008 | Anxiety Disorders |
| D001321 | Autistic Disorder |
| D016920 | Meningitis, Bacterial |
| D001714 | Bipolar Disorder |
| D002494 | Central Nervous System Infections |
| D012640 | Seizures |
| D017726 | Cytomegalovirus Retinitis |
| D004827 | Epilepsy |
| D006561 | Herpes Simplex |
| D018324 | Hemangioma, Capillary |
| D007239 | Infections |
| D007249 | Inflammation |
| D059413 | Intraabdominal Infections |
| D008881 | Migraine Disorders |
| D010146 | Pain |
| D011014 | Pneumonia |
| D012559 | Schizophrenia |
| D000090663 | Schizophrenia, Treatment-Resistant |
| D014552 | Urinary Tract Infections |
| D018805 | Sepsis |
| D001919 | Bradycardia |
| D006323 | Heart Arrest |
| D001145 | Arrhythmias, Cardiac |
| D013203 | Staphylococcal Infections |
| D000077299 | Healthcare-Associated Pneumonia |
| D004696 | Endocarditis |
| D009503 | Neutropenia |
| D006261 | Headache |
| D000081029 | Pulmonary Arterial Hypertension |
| D006973 | Hypertension |
| D051436 | Renal Insufficiency, Chronic |
| D006929 | Hyperaldosteronism |
| D007008 | Hypokalemia |
| D006333 | Heart Failure |
| D006467 | Hemophilia A |
| D008595 | Menorrhagia |
| D007319 | Sleep Initiation and Maintenance Disorders |
| D007251 | Influenza, Human |
| D008581 | Meningitis |
| D013035 | Spasm |
| D012173 | Retinitis |
| ID | Term |
|---|---|
| D004266 | DNA Virus Infections |
| D014777 | Virus Diseases |
| D001523 | Mental Disorders |
| D000067877 | Autism Spectrum Disorder |
| D002659 | Child Development Disorders, Pervasive |
| D065886 | Neurodevelopmental Disorders |
| D020806 | Central Nervous System Bacterial Infections |
| D001424 | Bacterial Infections |
| D001423 | Bacterial Infections and Mycoses |
| D002493 | Central Nervous System Diseases |
| D009422 | Nervous System Diseases |
| D000090862 | Neuroinflammatory Diseases |
| D000068105 | Bipolar and Related Disorders |
| D019964 | Mood Disorders |
| D009461 | Neurologic Manifestations |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D015828 | Eye Infections, Viral |
| D015817 | Eye Infections |
| D003586 | Cytomegalovirus Infections |
| D006566 | Herpesviridae Infections |
| D005128 | Eye Diseases |
| D012164 | Retinal Diseases |
| D001927 | Brain Diseases |
| D017193 | Skin Diseases, Viral |
| D012874 | Skin Diseases, Infectious |
| D012871 | Skin Diseases |
| D017437 | Skin and Connective Tissue Diseases |
| D006391 | Hemangioma |
| D009383 | Neoplasms, Vascular Tissue |
| D009370 | Neoplasms by Histologic Type |
| D009369 | Neoplasms |
| D010335 | Pathologic Processes |
| D051270 | Headache Disorders, Primary |
| D020773 | Headache Disorders |
| D012141 | Respiratory Tract Infections |
| D008171 | Lung Diseases |
| D012140 | Respiratory Tract Diseases |
| D019967 | Schizophrenia Spectrum and Other Psychotic Disorders |
| D014570 | Urologic Diseases |
| D052776 | Female Urogenital Diseases |
| D005261 | Female Urogenital Diseases and Pregnancy Complications |
| D000091642 | Urogenital Diseases |
| D052801 | Male Urogenital Diseases |
| D018746 | Systemic Inflammatory Response Syndrome |
| D006331 | Heart Diseases |
| D002318 | Cardiovascular Diseases |
| D016908 | Gram-Positive Bacterial Infections |
| D003428 | Cross Infection |
| D007049 | Iatrogenic Disease |
| D020969 | Disease Attributes |
| D000380 | Agranulocytosis |
| D007970 | Leukopenia |
| D000095542 | Cytopenia |
| D006402 | Hematologic Diseases |
| D006425 | Hemic and Lymphatic Diseases |
| D007960 | Leukocyte Disorders |
| D006976 | Hypertension, Pulmonary |
| D014652 | Vascular Diseases |
| D051437 | Renal Insufficiency |
| D007674 | Kidney Diseases |
| D002908 | Chronic Disease |
| D000308 | Adrenocortical Hyperfunction |
| D000307 | Adrenal Gland Diseases |
| D004700 | Endocrine System Diseases |
| D014883 | Water-Electrolyte Imbalance |
| D008659 | Metabolic Diseases |
| D009750 | Nutritional and Metabolic Diseases |
| D025861 | Blood Coagulation Disorders, Inherited |
| D001778 | Blood Coagulation Disorders |
| D020147 | Coagulation Protein Disorders |
| D006474 | Hemorrhagic Disorders |
| D030342 | Genetic Diseases, Inborn |
| D009358 | Congenital, Hereditary, and Neonatal Diseases and Abnormalities |
| D014592 | Uterine Hemorrhage |
| D014591 | Uterine Diseases |
| D005831 | Genital Diseases, Female |
| D000091662 | Genital Diseases |
| D006470 | Hemorrhage |
| D008599 | Menstruation Disturbances |
| D020919 | Sleep Disorders, Intrinsic |
| D020920 | Dyssomnias |
| D012893 | Sleep Wake Disorders |
| D009976 | Orthomyxoviridae Infections |
| D012327 | RNA Virus Infections |
| D020879 | Neuromuscular Manifestations |
Not provided
Not provided
| ID | Term |
|---|---|
| D000077404 | Cidofovir |
| D002939 | Ciprofloxacin |
| D008775 | Methylprednisolone |
| D014031 | Tobramycin |
| D015760 | Alfentanil |
| D003024 | Clozapine |
| D006220 | Haloperidol |
| D000069056 | Lurasidone Hydrochloride |
| D008972 | Molindone |
| D010424 | Pentobarbital |
| D014859 | Warfarin |
| C092292 | ziprasidone |
| D000583 | Amikacin |
| D000077723 | Cefepime |
| D009254 | Nafcillin |
| D000077725 | Piperacillin, Tazobactam Drug Combination |
| D000077123 | Rocuronium |
| D014673 | Vecuronium Bromide |
| D014640 | Vancomycin |
| D015119 | Aminocaproic Acid |
| D000077300 | Bosentan |
| D005578 | Fosfomycin |
| D007741 | Labetalol |
| D009543 | Nifedipine |
| D010098 | Oxycodone |
| D000069603 | Sevelamer |
| D013148 | Spironolactone |
| D014148 | Tranexamic Acid |
| D000077334 | Zolpidem |
| ID | Term |
|---|---|
| D063065 | Organophosphonates |
| D009943 | Organophosphorus Compounds |
| D009930 | Organic Chemicals |
| D003596 | Cytosine |
| D011744 | Pyrimidinones |
| D011743 | Pyrimidines |
| D006573 | Heterocyclic Compounds, 1-Ring |
| D006571 | Heterocyclic Compounds |
| D024841 | Fluoroquinolones |
| D042462 | 4-Quinolones |
| D015363 | Quinolones |
| D011804 | Quinolines |
| D006574 | Heterocyclic Compounds, 2-Ring |
| D000072471 | Heterocyclic Compounds, Fused-Ring |
| D011239 | Prednisolone |
| D011246 | Pregnadienetriols |
| D011245 | Pregnadienes |
| D011278 | Pregnanes |
| D013256 | Steroids |
| D000072473 | Fused-Ring Compounds |
| D011083 | Polycyclic Compounds |
| D009328 | Nebramycin |
| D007612 | Kanamycin |
| D000617 | Aminoglycosides |
| D006027 | Glycosides |
| D002241 | Carbohydrates |
| D005283 | Fentanyl |
| D010880 | Piperidines |
| D003984 | Dibenzazepines |
| D006575 | Heterocyclic Compounds, 3-Ring |
| D002090 | Butyrophenones |
| D007659 | Ketones |
| D013844 | Thiazoles |
| D013457 | Sulfur Compounds |
| D001393 | Azoles |
| D054833 | Isoindoles |
| D007211 | Indoles |
| D001463 | Barbiturates |
| D015110 | 4-Hydroxycoumarins |
| D003374 | Coumarins |
| D001578 | Benzopyrans |
| D011714 | Pyrans |
| D002511 | Cephalosporins |
| D047090 | beta-Lactams |
| D007769 | Lactams |
| D000577 | Amides |
| D013843 | Thiazines |
| D010406 | Penicillins |
| D000078142 | Tazobactam |
| D010397 | Penicillanic Acid |
| D010878 | Piperacillin |
| D000667 | Ampicillin |
| D010400 | Penicillin G |
| D013450 | Sulfones |
| D004338 | Drug Combinations |
| D004364 | Pharmaceutical Preparations |
| D000732 | Androstanols |
| D000731 | Androstanes |
| D006020 | Glycopeptides |
| D006001 | Glycoconjugates |
| D010455 | Peptides |
| D000602 | Amino Acids, Peptides, and Proteins |
| D000614 | Aminocaproates |
| D002208 | Caproates |
| D000144 | Acids, Acyclic |
| D002264 | Carboxylic Acids |
| D000596 | Amino Acids |
| D000096926 | Benzenesulfonamides |
| D013449 | Sulfonamides |
| D001555 | Benzene Derivatives |
| D006841 | Hydrocarbons, Aromatic |
| D006844 | Hydrocarbons, Cyclic |
| D006838 | Hydrocarbons |
| D004983 | Ethanolamines |
| D000605 | Amino Alcohols |
| D000438 | Alcohols |
| D012457 | Salicylamides |
| D000588 | Amines |
| D004095 | Dihydropyridines |
| D011725 | Pyridines |
| D003061 | Codeine |
| D009022 | Morphine Derivatives |
| D009019 | Morphinans |
| D053610 | Opiate Alkaloids |
| D000470 | Alkaloids |
| D006572 | Heterocyclic Compounds, Bridged-Ring |
| D006576 | Heterocyclic Compounds, 4 or More Rings |
| D010616 | Phenanthrenes |
| D011084 | Polycyclic Aromatic Hydrocarbons |
| D011073 | Polyamines |
| D007783 | Lactones |
| D011283 | Pregnenes |
| D003509 | Cyclohexanecarboxylic Acids |
| D000146 | Acids, Carbocyclic |
Not provided
Not provided