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| Name | Class |
|---|---|
| Duke University | OTHER |
| Johns Hopkins University | OTHER |
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This umbrella protocol seeks to develop robust data registries for non-communicable diseases (NCDs) in sub-Saharan Africa (SSA) with the aim of providing accurate and comprehensive data for the evaluation of such diseases in sub-Saharan African countries.Healthy volunteers will be included in the study for comparison.
Additionally, the investigators aim to describe the gut microbiome community diversity of a cohort of community dwelling Nigerians and compare with CRC patients in Nigerian and at MSK. We will collect stool for microbiome and metabolomic analysis from community dwelling persons in the catchment area of ARGO facilities in Nigeria while contemporaneously administering an extensive medical and environmental exposure questionnaire.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| healthy participants and participants diagnosed with NCDs | This protocol will entail prospective collection of data on healthy participants and participants diagnosed with NCDs managed at collaborating institutions in SSA. Information to be obtained includes socio-demographic data, risk factors, disease-specific data, investigation and treatment details, as well as findings during follow-up. Particular reference will be made to outcome measures such as local and distant recurrence, survival and mortality. Follow-up data will be updated during clinic visits and also via phone calls. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Questionnaire forms | Behavioral | The questionnaires will include information such as socio-demographic data, risk factors, disease specific data, investigation and treatment details as well as findings during followup. Particular reference will be made to outcome measures such as local and distant recurrence, survival and mortality. |
| Measure | Description | Time Frame |
|---|---|---|
| # of patients that develope non-communicable diseases in Africa | 5 years |
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Inclusion Criteria:
Exclusion Criteria:
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Participants will be accrued in medical clinics in Africa as determined by the local investigators and local research staff.
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| Name | Affiliation | Role |
|---|---|---|
| T. Peter Kingham, MD | Memorial Sloan Kettering Cancer Center | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Memorial Sloan Kettering Cancer Center | New York | New York | 10065 | United States | ||
| National Hospital of Abuja (Data collection only) |
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| Label | URL |
|---|---|
| Memorial Sloan Kettering Cancer Center | View source |
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Samples can include tissue, blood, urine, saliva, hair and nail clipping.
|
| Bio-specimen samples | Other | Samples can include tissue, blood, urine, saliva, hair and nail clipping. |
|
| Abuja |
| Central Business District |
| 900103 |
| Nigeria |
| Lagos State University Teaching Hospital | Idi-Araba | Lagos | Nigeria |
| Olabisis Onabanjo University Teaching Hospital | Sagamu | Ogun State | Nigeria |
| Federal Medical Centre Owo | Owo | Ondo State | Nigeria |
| University College Hospital | Ibadan | Oyo State | Nigeria |
| Ladoke Akintola University of Technology | Ogbomoso | Oyo State | Nigeria |
| University Of Nigeria Teaching Hospital (UNTH) Ituku-Ozalla Enugu | Enugu | Nigeria |
| Lagos State University Teaching Hospital | Ikeja | Nigeria |
| Obafemi Awolowo University Teaching Hospitals Complex (OAUTHC) | Ile-Ife | Nigeria |
| University of Ilorin Teaching Hospitals | Ilorin | Nigeria |
| University of Maiduguri Teaching Hospital (Data collection only) | Maiduguri | 600104 | Nigeria |
| Ondo State Trauma and Surgical Centre | Ondo | Nigeria |
| Federal Medical Centre Owo | Owo | Nigeria |
| ID | Term |
|---|---|
| D000073296 | Noncommunicable Diseases |
| ID | Term |
|---|---|
| D020969 | Disease Attributes |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
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