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The overall goal of the proposal is to improve capacity for detection and management of non-communicable diseases and geriatric syndromes in the aging HIV population in sub-Saharan Africa
The establishment and scale up of solid and sustainable HIV programs in sub-Saharan Africa (SSA) has led to a reduction in mortality and morbidity from HIV related opportunistic infections and some HIV related cancers. This improved survival has resulted in two phenomena: the first is the surfacing of non-communicable diseases (NCDs) in the HIV population, especially in those on long-term ART, and the second is increased longevity leading to increasing numbers of elderly HIV infected individuals
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Antiretroviral treatment | Drug | The cohort will recruit HIV infected participants who are on antiretroviral treatment |
|
| Measure | Description | Time Frame |
|---|---|---|
| Change in proportion of participants with any non communicable disease | Proportion with any non communicable disease (including hypertension, cardio vascular disease, respiratory disease, renal disease, non HIV related cancers, frailty) | Enrollment, year 1, year 2 |
| Change in Quality of life | Quality of life measured using the WHO Quality of life for elderly (WHOQOL-OLD) | Enrollment, year 1, year 2 |
| Measure | Description | Time Frame |
|---|---|---|
| Change in proportion of patients with polypharmacy monitoring | Polypharmacy defined as 5 or more drugs beyond antiretroviral drugs, used in the same individuals for more than 4 weeks. Information of polypharmacy will be collected by the clinic files and self reported by the participants | Enrollment, year 1, year 2 |
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Inclusion Criteria:
Age 60 years and above
Exclusion Criteria:
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All patients 60 years and above at IDI are referred to the elderly specialist clinic, which is run once a week by a physician, therefore study participants will be identified from this clinic. Enrolment into the Geriatric cohort will be offered to all patients 60 years and above attending attending their monthly routine clinic visit at the elderly specialist clinic will be approached by the study staff, will be given detailed information and be asked if they are willing to participate.
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Barbara Castelnuovo, PhD | Contact | 786623613 | 786623613 | bcastelnuovo@idi.co.ug |
| Phoebe Mbabazi, MMed | Contact | +256704918966 | phibsmm@gmail.com |
| Name | Affiliation | Role |
|---|---|---|
| Barbara Castelnuovo, PhD | Infectious Diseases Institute (IDI) | Principal Investigator |
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At the end of the project the dataset generated from the study will be made available as per the EDCTP Horizon 2020 guidelines. These data will be de-identified prior to sharing widely. The data will be shared in form an excel CSV spreadsheet that will be shared by the PI once the necessary approvals are met. We currently do not have a repository for the data, however at the time of publishing in Open Access Journals, the data will be made available
2025-2030
Approval from the PI
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| Type | Date | Date Unknown |
|---|---|---|
| Release | Apr 25, 2023 | |
| Reset | Jan 23, 2024 |
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| Release Date | Unrelease Date | Unrelease Date Unknown | Reset Date | MCP Release Number |
|---|---|---|---|---|
| Apr 25, 2023 | Jan 23, 2024 |
| ID | Term |
|---|---|
| D015658 | HIV Infections |
| D000073296 | Noncommunicable Diseases |
| ID | Term |
|---|---|
| D000086982 | Blood-Borne Infections |
| D003141 | Communicable Diseases |
| D007239 | Infections |
| D015229 | Sexually Transmitted Diseases, Viral |
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Packed cells Plasma Serum
| Change in Nutritional status assessed by Mini Nutritional Assessments (MNA) |
Nutrition screening and assessment to identify geriatric patients age who are malnourished or at risk of malnutrition. |
| Enrollment, year 1, year 2 |
| Change in proportion of patients with history of falls | Occurrence of falls measured with the History of Falls questionnaire | Enrollment, year 1, year 2 |
| Change in proportion of patients with urinary incontinence measured by ICIQ-UI Short | Presence of urinary incontinence measured with the Internal Consultation on Incontinence Questionnaire | Enrollment, year 1, year 2 |
| Change in proportion of patients with depression | Depression measurement using the People Health Questionnaire-9 (scale 0-30, higher: worse) | Enrollment, year 1, year 2 |
| Change in proportion of patients with disability | Assessment of the Instrumental Activities of Daily Living (score 0-8, higher: better) | Enrollment, year 1, year 2 |
| Change in proportion of patients with cognitive deficit | Screening using Montreal Cognitive Assessment (score 0-30; higher: better) | Enrollment, year 1, year 2 |
| D012749 | Sexually Transmitted Diseases |
| D016180 | Lentivirus Infections |
| D012192 | Retroviridae Infections |
| D012327 | RNA Virus Infections |
| D014777 | Virus Diseases |
| D000091662 | Genital Diseases |
| D000091642 | Urogenital Diseases |
| D007153 | Immunologic Deficiency Syndromes |
| D007154 | Immune System Diseases |
| D020969 | Disease Attributes |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |