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Aim of study : Assessement of neutrophil activation during ischemia reperfusion associated with tourniquet use for total knee arthroplasty. This activation was compared in a group of patient scheduled for spinal anesthesia and for sevoflurane anesthesia
Aim of study : Assessement of neutrophil activation during ischemia reperfusion associated with tourniquet use for total knee arthroplasty. This activation was compared in a group of patient scheduled for spinal anesthesia and for sevoflurane anesthesia This activation was assessed by plasma myeloperoxidase and elastase measurements in four consecutive blood samples during and after surgery (before surgical incision and 1, 3, 24 hours following tourniquet release.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Group Spinal anesthesia | Active Comparator | Knee surgery under spinal anesthesia Intervention involves spinal administration of 12,5 mg bupivacaine and 2,5 microgram sufentanil. |
|
| Group Sevoflurane anesthesia | Active Comparator | Knee surgery under sevoflurane anesthesia Intervention involves administration of inhaled sevoflurane for maintenance of general anesthesia |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Sevoflurane Volatile Liquid | Drug |
| ||
| Bupivacaine / SUFentanil |
| Measure | Description | Time Frame |
|---|---|---|
| Changes in plasmatic concentration of myeloperoxidase and elastase | Biological measurement of changes in plasmatic concentration of myeloperoxidase and elastase from preoperative values to one hour after tourniquet release. | Before surgical incision and one hour after tourniquet release |
| Changes in plasmatic concentration of myeloperoxidase and elastase | Biological measurement of changes in plasmatic concentration of myeloperoxidase and elastase from preoperative values to 3 and 24 hours after tourniquet release. | Before surgical incision then 3 and 24 hours after tourniquet release |
| Measure | Description | Time Frame |
|---|---|---|
| Changes in plasmatic concentration of endothelial biomarkers | Biological measurement of changes in plasmatic concentration of syndecan-1, soluble thrombomodulin, soluble E-selectin and VEGF from preoperative values to one hour after tourniquet release. | Before surgical incision and one hour after tourniquet release |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Jean-François Brichant, MD, PhD | University of Liege | Study Chair |
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| ID | Term |
|---|---|
| D002045 | Bupivacaine |
| D017409 | Sufentanil |
| ID | Term |
|---|---|
| D000813 | Anilides |
| D000577 | Amides |
| D009930 | Organic Chemicals |
| D000814 | Aniline Compounds |
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| Drug |
|
| Changes in plasmatic concentration of endothelial biomarkers |
Biological measurement of changes in plasmatic concentration of syndecan-1, soluble thrombomodulin, soluble E-selectin and VEGF from preoperative values to 3 and 24 hours after tourniquet release. |
| Before surgical incision then 3 and 24 hours after tourniquet release |
| D000588 |
| Amines |
| D005283 | Fentanyl |
| D010880 | Piperidines |
| D006573 | Heterocyclic Compounds, 1-Ring |
| D006571 | Heterocyclic Compounds |