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Clinical, Biochemical and Neurophysiological Consequences of Intraoperative Tourniquet During Total Knee Arthroplasty:
WOMAC-Score Knee-Score Radiographic Evaluations and Scoring System Biochemical muscle biopsy analysis
Biochemistry: Analysis of the muscles biopsies Clinical: Bloodloss, Complications, WOMAC-Score, Knee-Score Radiographics: Evaluations and Scoring System Neurophysiology Evaluation of N. femoralis
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| tourniquet | Experimental | Total knee arthroplasty will be performed with tourniquet |
|
| non-tourniquet | Experimental | Total knee arthroplasty will be performed without tourniquet |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Total knee arthroplasty | Procedure | Total knee arthroplasty |
|
| Measure | Description | Time Frame |
|---|---|---|
| Biochemical Data | Measurement of intracellular proteolytic activity | During operation 60 min Ischemia/Shame-Ischemia Time |
| Measure | Description | Time Frame |
|---|---|---|
| Bloodloss | 1 week postoperative | |
| Complications | 6 months postoperative | |
| Clinical Scores |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Ahmed Jawhar, Dr | Contact | 0621-3834500 | umm | jawhar_ahmed@yahoo.de |
| Name | Affiliation | Role |
|---|---|---|
| Udo Obertacke, Prof. Dr. | UMM | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| UMM | Recruiting | Mannheim | Badenwürtemberg | 68167 | Germany |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 25219028 | Background | Girard N. Evidence appraisal of Zhang W, Li N, Chen S, Tan Y, Al-Aidaros M, Chen L. The effects of a tourniquet used in total knee arthroplasty: a meta-analysis. J Orthop Surg Res. 2014;9(1):13. http://www.josr-online.com/content/9/1/13. Accessed May 30, 2014. AORN J. 2014 Aug;100(2):224-8. doi: 10.1016/j.aorn.2014.06.003. No abstract available. | |
| 31372679 |
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| ID | Term |
|---|---|
| D019645 | Arthroplasty, Replacement, Knee |
| ID | Term |
|---|---|
| D019643 | Arthroplasty, Replacement |
| D001178 | Arthroplasty |
| D019637 | Orthopedic Procedures |
| D013514 | Surgical Procedures, Operative |
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WOMAC-Score, Knee-Score
| 6 months postoperative |
| Radiographic Scores | Prosthesis Position on radiographs | 1 Week postoperative |
| Electrophysiological Evaluation of the N. femoralis | Nerve function analysis | 1 Week postoperative |
| Jawhar A, Skeirek D, Stetzelberger V, Kollowa K, Obertacke U. No effect of tourniquet in primary total knee arthroplasty on muscle strength, functional outcome, patient satisfaction and health status: a randomized clinical trial. Knee Surg Sports Traumatol Arthrosc. 2020 Apr;28(4):1045-1054. doi: 10.1007/s00167-019-05646-5. Epub 2019 Aug 1. |
| D019651 | Plastic Surgery Procedures |
| D019919 | Prosthesis Implantation |