Clinical, Biochemical and Neurophysiological Consequences of Intraoperative Tourniquet During Total Knee Arthroplasty

Clinical, Biochemical and Neurophysiological Consequences of Intraoperative

Clinical, Biochemical and Neurophysiological Consequences of Intraoperative Tourniquet During Total Knee Arthroplasty:

WOMAC-Score Knee-Score Radiographic Evaluations and Scoring System Biochemical muscle biopsy analysis

Biochemistry: Analysis of the muscles biopsies Clinical: Bloodloss, Complications, WOMAC-Score, Knee-Score Radiographics: Evaluations and Scoring System Neurophysiology Evaluation of N. femoralis

Inclusion Criteria:

• Age = 55-85 years
• Osteoarthritis of knee joint (degree III or IV)
• Physical status (ASA I or II)
• Body mass index < 45 kg/m²
• Written informed consent

Exclusion Criteria:

• Age <55 or > 85years
• Osteoarthritis knee joint (degree I or II)
• Physical status (ASA III or IV)
• Body mass index ≥ 45 kg/m²
• Unable to provide written consent
• Malignant disease
• Rheumatoid disease
• Infectious disease
• Coagulation disorder
• History of deep vein thrombosis or pulmonary embolism
• Peripheral arterial disease
• Immune deficiency
• Medication (Glucocorticoid, Aspirin, Heparin, Cumardine, Wafarin)
• Neurological dysfunction
• Liver insufficiency
• Coronary heart disease
• Immobility