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| ID | Type | Description | Link |
|---|---|---|---|
| R00ES023498 | U.S. NIH Grant/Contract | View source |
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| Name | Class |
|---|---|
| National Institute of Environmental Health Sciences (NIEHS) | NIH |
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This study uses an experimental design to conduct a double-blind, randomized, crossover study where participants receive both diesel exhaust and a mental stress test in a controlled setting. My hypothesis is that the synergistic effect of stress and air pollution will result in higher levels of stress and inflammation (measured via biological markers) as well as poorer cardiovascular disease related outcomes compared to the independent effect of each exposure separately.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Filtered Air | No Intervention | Subjects sit in a room for two hours breathing in filtered air which resembles levels of air pollution found in the ambient environment | |
| Diesel Exhaust | Active Comparator | Subjects sit in a room for two hours breathing in diesel exhaust at 200 micrograms of meter cubed. |
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| TSST/Stress only | Active Comparator | Subjects undergo a mental stress test, known as the Trier Social Stress Test (TSST), which involves a public speaking and math task. |
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| Diesel Exhaust and stress | Active Comparator | Subjects sit in a room for two hours breathing in diesel exhaust at 200 micrograms of meter cubed and are subject to a mental stress test (TSST) which involves a public speaking and math task. |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Trier social stress test | Behavioral | Subjects are asked to give a 5 minute speech on a topic selected by the investigator. Then they are asked to subtract 7 from 758. |
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| Measure | Description | Time Frame |
|---|---|---|
| Change in norepinephrine | Urinary norepinephrine in ng/mg | Change in norepinephrine from baseline (pre-exposure) to immediately after exposure |
| Change in epinephrine | Urinary epinephrine in ng/mg | Change in epinephrine from baseline (pre-exposure) to immediately after exposure |
| Change in dopamine | Urinary dopamine in ng/mg | Change in dopamine from baseline (pre-exposure) to immediately after exposure |
| Measure | Description | Time Frame |
|---|---|---|
| Change in d-dimer | plasma d-dimer (ug/ml) is a measure of coagulation | change in d-dimer from baseline (pre-exposure) to six hours post exposure |
| Change in fibrinogen | plasma fibrinogen (mg/dl) is a measure of coagulation |
| Measure | Description | Time Frame |
|---|---|---|
| Change in blood pressure | blood pressure in mm Hg | Change in blood pressure from baseline (pre-exposure) to 22 hours post exposure |
| Change in heart rate | heart rate in beats per minute |
Inclusion Criteria:
Non-smokers without history of high blood pressure, asthma, diabetes, high cholesterol, post-traumatic stress disorder (PTSD) or any other chronic condition that requires ongoing care.
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Karen Jansen, MS | Contact | 206-685-6392 | kjansen@uw.edu |
| Name | Affiliation | Role |
|---|---|---|
| Anjum Hajat, PhD | University of Washington | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University of Washington Diesel Exhaust Facility | Recruiting | Seattle | Washington | 98195 | United States |
We may share some of the clinical data collected such as blood pressure, spirometry and other markers of cardiac function with researchers interested in addressing related study questions. Direct identifiers will not be stored or shared, but rather only de-identified bio-specimens and data.
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| ID | Term |
|---|---|
| D007249 | Inflammation |
| ID | Term |
|---|---|
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
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| ID | Term |
|---|---|
| D011581 | Psychological Tests |
| D001335 | Vehicle Emissions |
| ID | Term |
|---|---|
| D004191 | Behavioral Disciplines and Activities |
| D045424 | Complex Mixtures |
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| Diesel exhaust | Other | Diesel exhaust is an air pollutant found in the environment and produced by cars, trucks and other transportation modes (e.g. trains, planes). |
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| change in fibrinogen from baseline (pre-exposure) to six hours post exposure |
| Change in interleukin-6 (IL-6) | plasma IL-6, measured in pg/ml, is a marker of inflammation | change in IL-6 from baseline (pre-exposure) to immediately after exposure |
| Change in tumor necrosis factor alpha (TNF-a) | plasma TNF-a, measured in pg/ml, is a marker of inflammation | change in TNF-a from baseline (pre-exposure) to immediately after exposure |
| Change in interleukin-1b (IL-1b) | plasma IL-1b, measured in pg/ml, is a marker of inflammation | change in IL-1b from baseline (pre-exposure) to immediately after exposure |
| Change in blood pressure from baseline (pre-exposure) to 60 minutes post exposure |