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| ID | Type | Description | Link |
|---|---|---|---|
| P50ES015915 | U.S. NIH Grant/Contract | View source |
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| Name | Class |
|---|---|
| National Institute of Environmental Health Sciences (NIEHS) | NIH |
| Environmental Protection Agency (EPA) | FED |
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Double-blind, sham- and placebo-controlled randomized study of effects of freshly-generated diluted diesel exhaust inhalation on vascular function. To examine role of adrenergic system a trial of alpha-blocker terazosin is also used. Each participant completes four study sessions, separated by at least three weeks: 1) Diesel exhaust inhalation (DE, controlled at 300 micrograms/cubic meter for two hours) and terazosin (2 mg prior to inhalation exposure); 2) DE plus placebo (matched for terazosin); 3) filtered air plus terazosin; and 4) filter air plus placebo. The investigators assess outcomes of blood pressure, forearm brachial artery ultrasound, and plasma measures of endothelial activation. The investigators hypothesize that DE exposure will be associated with increased blood pressure, decreased brachial artery diameter, and increased circulating endothelins, and that these effects will be attenuated by terazosin administration.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Diesel Exhaust + Terazosin | Experimental |
| |
| Diesel Exhaust + placebo | Experimental |
| |
| Filtered Air + terazosin | Sham Comparator |
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| Filtered air + placebo | Sham Comparator |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Diesel Exhaust | Other | Freshly generated diesel exhaust, diluted to 300 micrograms/cubic meter. Exposures are two hours in duration. |
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| Measure | Description | Time Frame |
|---|---|---|
| Systolic Blood Pressure | 30-90 minutes after exposure initiation |
| Measure | Description | Time Frame |
|---|---|---|
| Brachial artery diameter | The investigators anticipate vasoconstriction (post-exposure vs. pre-exposure) as observed in this conduit artery in response to exposure to Diesel Exhaust, compared to Filtered Air sham exposure. | Assessed 30 minutes prior to exposure and 30 minutes post-exposure |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Karen Jansen, M.S. | Contact | 206-616-6525 | cvd1trap@uw.edu |
| Name | Affiliation | Role |
|---|---|---|
| Joel D Kaufman, MD, MPH | University of Washington | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University of Washington Medical Center | Recruiting | Seattle | Washington | 98195 | United States |
| Type | Date | Date Unknown |
|---|---|---|
| Release | Apr 16, 2019 | |
| Reset | May 7, 2019 | |
| Release | Oct 15, 2021 | |
| Reset | Nov 10, 2021 |
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| Release Date | Unrelease Date | Unrelease Date Unknown | Reset Date | MCP Release Number |
|---|---|---|---|---|
| Apr 16, 2019 | May 7, 2019 | |||
| Oct 15, 2021 |
| ID | Term |
|---|---|
| D001335 | Vehicle Emissions |
| C041226 | Terazosin |
| ID | Term |
|---|---|
| D045424 | Complex Mixtures |
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| Filtered Air | Other | Sham exposure, identical to conditions of diesel exhaust exposure, but with only air filtered of particles and volatile organic compound gases |
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| Terazosin | Drug | 2 mg by mouth, 90 minutes prior to exposure initiation |
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| placebo | Drug | capsule, identical in appearance to terazosin capsule, by mouth, 30 minutes prior to exposure initiation |
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| Nov 10, 2021 |