DNA Methylation and Hydroxymethylation Levels in Patients With Coronary Heart Disease

DNA Methylation and Hydroxymethylation Levels in Patients With Coronary Heart Disease

The purpose of this trial is to investigate the relationship between DNA methylation and hydroxymethylation and the expression of DNMTs, TET family gene and the degree of coronary heart disease.

1. To determine the levels of DNA methylation and hydroxymethylation with coronary heart disease.
2. To investigate the relationship between DNA methylation and hydroxymethylation and the degree of coronary atherosclerosis.

Inclusion Criteria:

Male and Female. Patients older than 65 years old who are willing to participate in the study. CHD patients was defined as at least one lesion in a coronary artery or branches in coronary angiograms. Control group was defined as people with negative findings in coronary angiograms.

Exclusion Criteria:

Patients with concurrent infection or any documented inflammatory illness, such as arthritis or connective tissue diseases, or any other malignancy. Patients with a history of cardiomyopathy. Pregnant women. Severe hepatic dysfunction or End-stage renal failure. Uncontrolled hypertension.