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| Name | Class |
|---|---|
| Nanjing Maternity and Child Health Care Hospital | OTHER |
| Jiangsu Women and Children Health Hospital | UNKNOWN |
| The First People's Hospital of Lianyungang | OTHER |
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Twenty-seven hospitals in China will participate in the study, which aims to increase breastfeeding rate in the neonatal intensive care unit (NICU) and reduce the clinical complications in very low birth weight infants and extremely low birth weight infants.
Breast milk reduces the risk of serious prematurity related morbidities. Quality improvement is an effective means of increasing breast milk feeding.Twenty-seven hospitals in China will participate in the study, which aims to increase breastfeeding rate in the NICU and reduce the clinical complications in very low birth weight infants and extremely low birth weight infants. This study compared the clinical data of very low birth weight infants and extremely low birth weight infants in three phases：Before-intervention phase，Intervention phase and Sustainability phase. During the Intervention phase and Sustainability phase multiple intervention bundles of quality improvement were implemented.The investigators will compare breast milk feeding rate and neonatal outcomes in different phases.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Before-intervention phase | No Intervention | All the very low birth weight (VLBW) and extremely low birth weight (ELBW) infants who were admitted from January 2017 to December 2017 to the NICUs of different hospitals. | |
| Intervention phase | Experimental | All the VLBW and ELBW infants who were admitted from January 2018 to December 2018 to the NICUs.During this phase,multiple intervention bundles of quality improvement will be implemented. |
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| Sustainability intervention phase | Experimental | All the VLBW and ELBW infants who were admitted from January 2019 to December 2019to the NICUs.In the Sustainability intervention phase,multiple intervention bundles of quality improvement will be continuous implemented. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Quality improvement of breast milk feeding | Behavioral | During the Intervention phase and Sustainability phase ,The NICUs will receive training of multiple evidence based quality improvement methods. |
| Measure | Description | Time Frame |
|---|---|---|
| mother own milk feeding rates | three years |
| Measure | Description | Time Frame |
|---|---|---|
| NICU costs | costs during hospitalization in NICU | three years |
| the incidence of necrotizing enterocolitis (NEC) | the incidence of necrotizing enterocolitis |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Shuping Han, PhD | Nanjing Maternity and Child Health Care Hospital | Study Director |
| Zhangbin Yu, PhD | Nanjing Maternity and Child Health Care Hospital | Study Director |
| Jun Zhang, PhD | Nanjing Maternity and Child Health Care Hospital | Principal Investigator |
| Yuhua Hu, PhD | Jiangsu Women and Children Health Hospital | Principal Investigator |
| Shan Li, PhD | The First People's Hospital of Lianyungang | Principal Investigator |
| Xiaoyi Deng, PhD | Xuzhou Maternity and Child Health Care Hospital | Principal Investigator |
| Zelin Jiao, PhD | The Second Hospital of Nanjing Medical University | Principal Investigator |
| Rui Cheng, PhD | Children's Hospital of Nanjing Medical University | Principal Investigator |
| Weiyuan Wang, PhD | Suqian Maternity and Child Health Care Hospital |
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| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 33190629 | Derived | Xu Y, Yu Z, Li Q, Zhou J, Yin X, Ma Y, Yin Y, Jiang S, Zhu R, Wu Y, Han L, Gao Y, Xue M, Qiao Y, Zhu L, Tu W, Wu M, Wan J, Wang W, Deng X, Li S, Wang S, Chen X, Zhou Q, Wang J, Cheng R, Wang J, Han S. Dose-dependent effect of human milk on Bronchopulmonary dysplasia in very low birth weight infants. BMC Pediatr. 2020 Nov 16;20(1):522. doi: 10.1186/s12887-020-02394-1. |
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| Xuzhou Maternity and Child Health Care Hospital |
| OTHER |
| The Second Hospital of Nanjing Medical University | OTHER |
| Children's Hospital of Nanjing Medical University | OTHER |
| Suqian Maternity and Child Health Care Hospital | UNKNOWN |
| Lianyungang Maternity and Child Health Care Hospital | UNKNOWN |
| Wuxi Women's & Children's Hospital | OTHER |
| Suzhou Municipal Hospital | OTHER |
| Yancheng Maternity and Child Health Care Hospital | UNKNOWN |
| The First People's Hospital of Yancheng | UNKNOWN |
| The Affiliated Jiangyin Hospital of Southeast University Medical College | UNKNOWN |
| The First People's Hospital of Zhangjiagang | UNKNOWN |
| The Affiliated Huaian NO.1 People's Hospital of Nanjing Medical University | UNKNOWN |
| Huaian Maternity and Child Health Care Hospital | UNKNOWN |
| Changzhou Maternal and Child Care Hospital | OTHER |
| Zhenjiang Maternity and Child Health Care Hospital | UNKNOWN |
| The Affiliated Hospital of Xuzhou Medical University | OTHER |
| Jiangsu Taizhou People's Hospital | OTHER |
| Affiliated Hospital of Jiangsu University | OTHER |
| First People's Hospital of Hangzhou | OTHER |
| Wuxi Maternity and Child Health Care Hospital | OTHER |
| Changzhou Children's Hospital | UNKNOWN |
| Northern Jiangsu People's Hospital | OTHER |
| Children's Hospital of Soochow University | OTHER |
| Nantong Maternity and Child Health Care Hospital | UNKNOWN |
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| three years |
| the incidence of sepsis | three years |
| Reduce the incidence of enteral feed intolerance | three years |
| Yan Gao, PhD | Lianyungang Maternity and Child Health Care Hospital | Principal Investigator |
| Zhengying Li, PhD | Wuxi Women's & Children's Hospital | Principal Investigator |
| Sannan Wang, PhD | Suzhou Municipal Hospital | Principal Investigator |
| Jinlan Chai, PhD | Yancheng Maternity and Child Health Care Hospital | Principal Investigator |
| Zhun xu, PhD | The First People's Hospital of Yancheng | Principal Investigator |
| Jun Wan, PhD | The Affiliated Jiangyin Hospital of Southeast University Medical College | Principal Investigator |
| Weidong xu, PhD | The First People's Hospital of Zhangjiagang | Principal Investigator |
| Zhaofang Tian, PhD | The Affiliated Huaian NO.1 People's Hospital of Nanjing Medical University | Principal Investigator |
| Liangrong Han, PhD | Huaian Maternity and Child Health Care Hospital | Principal Investigator |
| Jinxiu Wang, PhD | Changzhou Maternal and Child Care Hospital | Principal Investigator |
| Xuqin Mao, PhD | Zhenjiang Maternity and Child Health Care Hospital | Principal Investigator |
| Jun Wang, PhD | The Affiliated Hospital of Xuzhou Medical University | Principal Investigator |
| Mei Xue, PhD | Jiangsu Taizhou People's Hospital | Principal Investigator |
| Hongyan Lu, PhD | Affiliated Hospital of Jiangsu University | Principal Investigator |
| Mingfu Wu, PhD | First People's Hospital of Hangzhou | Principal Investigator |
| Qin Zhou, PhD | Wuxi Maternity and Child Health Care Hospital | Principal Investigator |
| Wenjuan Tu, PhD | Changzhou Children's Hospital | Principal Investigator |
| Lingling Zhu, PhD | Northern Jiangsu People's Hospital | Principal Investigator |
| Bin Sun, PhD | Children's Hospital of Soochow University | Principal Investigator |
| Shuangshuang Li, PhD | Nantong Maternity and Child Health Care Hospital | Principal Investigator |
| Xiaohui Chen, PhD | Nanjing Maternity and Child Health Care Hospital | Principal Investigator |