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Thoracoabdominal oesophageal resection for cancer is a procedure with high risks for complications, and patients' preoperative status is a crucial factor for outcome. There are only a few studies that evaluate the effect of preoperative intervention, including physical exercises and breathing exercises, after this type of surgery.
The aim of the study is therefore to evaluate the effect of a training intervention before resection of the oesophagus.
One hundred patients scheduled for oesophagus resection according to Ivor-Lewis from five different hospitals in Sweden will be included. The patients will be randomized to an intervention group or a control group. The training intervention starts directly after preoperative radiotherapy and chemotherapy are given and lasts until three months postoperatively.
Intervention includes increased physical activity, strength training and respiratory muscle training.
At inclusion and three months after discharge, the patients will undergo tests of physical function and lung function. In addition, they will fill in questionnaires concerning level of physical function, level of physical activity and quality of life. These questionnaires will also be answered one year after surgery.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Pretraining | Experimental | Increased physical activity daily Daily strength training Daily inspiratory and expiratory muscle training Standard care during hospital stay and continued training after discharge. |
|
| Usual care treatment | Active Comparator | Standard care including preoperative information and postoperative breathing exercises and mobilization during hospital stay. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Pretraining | Other | Increased physical activity, and daily strength training and breathing exercises. |
|
| Measure | Description | Time Frame |
|---|---|---|
| 6 minutes walk test | Test of physical capacity | From inclusion to 3 months postoperatively |
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| Measure | Description | Time Frame |
|---|---|---|
| Spirometry | Vital capacity | From inclusion to 3 months postoperatively |
| Respiratory muscle strength | Maximal Inspiratory Pressure and maximal expiratory pressure |
Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Monika Fagevik Olsén, phD | Sahlgrenska Academy at Gothenburg university, Sweden | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Sahlgrenska University Hospital | Gothenburg | 413 45 | Sweden |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 41372748 | Derived | Fagevik Olsen M, Lothgren S, Trolle U, Elf E, Toomvali-Petersson S, Hermansson M, Hammerlid E, Smedh U. Positive effects of a perioperative training intervention in Ivor Lewis oesophageal surgery: a randomised, controlled multicentre trial. BMC Surg. 2025 Dec 11;26(1):34. doi: 10.1186/s12893-025-03416-4. |
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| ID | Term |
|---|---|
| D004938 | Esophageal Neoplasms |
| D009043 | Motor Activity |
| ID | Term |
|---|---|
| D005770 | Gastrointestinal Neoplasms |
| D004067 | Digestive System Neoplasms |
| D009371 | Neoplasms by Site |
| D009369 | Neoplasms |
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A single blind, randomized, controlled, intervention study. Evaluation of the addition of increased physical activity and respiratory muscle training for patients undergoing thoracoabdominal esophagus resection compared to standard care
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Assessor will not be aware of which group the patients are included in.
| Usual care | Other | Preoperative information |
|
| From inclusion to 3 months postoperatively |
| Hand strength | Hand strength (Jamar) | From inclusion to 3 months postoperatively |
| Leg strength- calf strength | Heel rise test | From inclusion to 3 months postoperatively |
| Leg strength | Chair stands test | From inclusion to 3 months postoperatively |
| Rib cage range of motion | Chest excursion and Respiratory Movement Measurement Instrument | From inclusion to 3 months postoperatively |
| Level of physical activity | Scale by Grimby and Frändin | From inclusion to 1 year postoperatively (The whole study period) |
| Physical function | Disability Rating Index | From inclusion to 1 year postoperatively (The whole study period) |
| Postoperative recovery | The Postoperative Recovery Profile | From surgery to 1 year postoperatively |
| Pain in the ribcage | Numeric rating scale, Scale from 0-10 where 0 indicates no pain and 10 worst imaginable pain | From inclusion to 1 year postoperatively (The whole study period) |
| Generic Quality of life | EORTC 3 modules | From inclusion to 1 year postoperatively (The whole study period) |
| D006258 |
| Head and Neck Neoplasms |
| D004066 | Digestive System Diseases |
| D004935 | Esophageal Diseases |
| D005767 | Gastrointestinal Diseases |
| D001519 | Behavior |