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This study will compare the outcome after surgery between a group of patients that receives instructions for prehabilitation training and one group that received standard treatment.
The aim of this study is to investigate whether a training program with intensified physical activity prior to and after a surgical procedure reduces the surgical-related postoperative recovery time, hospital stay, sick leave and complication rate.
A secondary aim is to investigate the effect of a training program with pre- and post- operative PA on the rate of resumption of QoL and normal physical function.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Pre and postoperative exercise | Experimental | The intervention is prehabilitation preoperatively and physical training postoperatively. During the hospital stay both groups will be treated in the same manner. Preoperative intervention: One half hour of exercise daily added to the existing daily exercise routine. The level of exercise should produce shortness of breath but the patient should be able to talk without much effort. Inspiratory muscle training. Thirty breaths x two twice daily. Postoperative intervention is mainly the same as preoperatively. |
|
| Control | No Intervention | Standard treatment with one exception, patients will fill in a physical activity diary |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Physical activity | Other | The intervention will take place both pre- and postoperatively. During the hospital stay both groups will be treated in the same manner. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Recovery measured as physical recovery measured in questionnaire | 4-6 weeks |
| Measure | Description | Time Frame |
|---|---|---|
| Psychological recovery measured in a questionnaire, patient reported | Recovery | 4-6 weeks and 1 year post-operatively |
| Recovery measured as time back to work | Recovery |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Eva Haglind, M.D., Ph.D. | SSORG | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Sahlgrenska University Hospital/Östra | Gothenburg | 416 85 | Sweden | |||
| Dept. of Surgery, Skaraborgs Sjukhus |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 38225857 | Derived | Onerup A, Li Y, Afshari K, Angenete E, de la Croix H, Ehrencrona C, Wedin A, Haglind E. Long-term results of a short-term home-based pre- and postoperative exercise intervention on physical recovery after colorectal cancer surgery (PHYSSURG-C): a randomized clinical trial. Colorectal Dis. 2024 Mar;26(3):545-553. doi: 10.1111/codi.16860. Epub 2024 Jan 15. | |
| 37162250 |
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| ID | Term |
|---|---|
| D015179 | Colorectal Neoplasms |
| D009043 | Motor Activity |
| ID | Term |
|---|---|
| D007414 | Intestinal Neoplasms |
| D005770 | Gastrointestinal Neoplasms |
| D004067 | Digestive System Neoplasms |
| D009371 | Neoplasms by Site |
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| ID | Term |
|---|---|
| D015444 | Exercise |
| ID | Term |
|---|---|
| D009043 | Motor Activity |
| D009068 | Movement |
| D009142 | Musculoskeletal Physiological Phenomena |
| D055687 | Musculoskeletal and Neural Physiological Phenomena |
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| 1 year |
| Complications according to Clavien-Dindo | Postoperative complications | within 90 days |
| QoL measured using SF-36 | QoL according to SF-36 | 4-6 weeks and 1 year |
| QoL measured using EQ-5D | QoL according to EQ-5D | 4-6 weeks and 1 year |
| QoL measured using a specifically developed instrument for this study | Health related QoL | 4-6 weeks and 1 year |
| Mortality | Long term mortality | 3 and 5 years |
| Re-admissions | Hospital re-admissions | 1 year |
| Reoperations | Reoperations | 1 year |
| Total time of hospital stay | Length of stay | 1 year |
| IGF-1 and IGFBP-3 | Lab values | 4 weeks postopeartively |
| Postoperative pain measured with Brief Pain Inventory-Short form | Pain measured by BPI-S | 4 weeks |
| Postoperative pain measured with Brief Pain Inventory-Short form | Pain measured by BPI-S | 12 months |
| Health economic analysis | Health economic analysis modified according to results of primary outcome | 4 weeks |
| Health economic analysis | Health economic analysis modified according to results of primary outcome | 12 months |
| Skövde |
| Sweden |
| Molenaar CJ, van Rooijen SJ, Fokkenrood HJ, Roumen RM, Janssen L, Slooter GD. Prehabilitation versus no prehabilitation to improve functional capacity, reduce postoperative complications and improve quality of life in colorectal cancer surgery. Cochrane Database Syst Rev. 2023 May 10;5(5):CD013259. doi: 10.1002/14651858.CD013259.pub3. |
| 35588252 | Derived | Molenaar CJ, van Rooijen SJ, Fokkenrood HJ, Roumen RM, Janssen L, Slooter GD. Prehabilitation versus no prehabilitation to improve functional capacity, reduce postoperative complications and improve quality of life in colorectal cancer surgery. Cochrane Database Syst Rev. 2022 May 19;5(5):CD013259. doi: 10.1002/14651858.CD013259.pub2. |
| 32007834 | Derived | Onerup A, Thorn SE, Angenete E, Bock D, Gryback Gillheimer E, Haglind E, Nilsson H. Effects of a home-based exercise program on the insulin-like growth factor axis in patients operated for colorectal cancer in Sweden: Results from the randomised controlled trial PHYSSURG-C. Growth Horm IGF Res. 2020 Apr;51:27-33. doi: 10.1016/j.ghir.2020.01.005. Epub 2020 Jan 28. |
| 28482864 | Derived | Onerup A, Angenete E, Bock D, Borjesson M, Fagevik Olsen M, Gryback Gillheimer E, Skullman S, Thorn SE, Haglind E, Nilsson H. The effect of pre- and post-operative physical activity on recovery after colorectal cancer surgery (PHYSSURG-C): study protocol for a randomised controlled trial. Trials. 2017 May 8;18(1):212. doi: 10.1186/s13063-017-1949-9. |
| D009369 | Neoplasms |
| D004066 | Digestive System Diseases |
| D005767 | Gastrointestinal Diseases |
| D003108 | Colonic Diseases |
| D007410 | Intestinal Diseases |
| D012002 | Rectal Diseases |
| D001519 | Behavior |