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The investigators aimed to investigate TGFB1 and LAMA1 gene polymorphisms in children with high myopia in order to determine the genetic basis of large myopic shifts causing severe visual impairment and complications.
Seventy-four children with high myopia (≥6 diopters [D]; study group) and 77 emmetropic children (±0.5D; control group) were included. Genetic and polymorphism analyses were performed in the Medical Genetics Laboratory using DNA purified from the patients' blood samples.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Study group | Active Comparator | Children with cycloplegia refractive error more than -6 D TGFB1 AND LAMA1 GENE POLYMORPHISMS were examined |
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| Control group | Other | Emmetropic children TGFB1 AND LAMA1 GENE POLYMORPHISMS were examined |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| TGFB1 AND LAMA1 GENE POLYMORPHISMS | Genetic | we evaluated polymorphisms in the LAMA1 (rs2089760) and TGFB1 (rs4803455) genes in children younger than 13 years of age with ≥6 D myopia in an attempt to further elucidate the genetic basis of high myopia. |
| Measure | Description | Time Frame |
|---|---|---|
| Genetic basis of high myopia | evaluated polymorphisms in the LAMA1 (rs2089760) and TGFB1 (rs4803455) genes in children younger than 13 years of age with ≥6 D myopia | 4 years |
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Inclusion Criteria:
Exclusion Criteria:
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