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As one of the essential micronutrients, selenium has important biological functions. However, an effective and convenient method for evaluation of selenium nutritional status has not yet been established. Previous literature has disclosed effect of selenium deficiency on inactivating glutathion peroxidase and deiodinase, which may cause decreased conversion from thyroxine ( T4) to triiodothyronine (T3). A case-control study is designed to demonstrate the association between selenium deficiency and abnormally elevated T4 or T4/T3, which may provide more clues for establishing effective selenium assesment methods.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| group with normal T4 level or T4/T3 | participants with T4 within 4.3-12.5ug/dl and ratio of T4/T3(T4(ug/dl)/T3 (ng/ml)) ≤7.52, which are considered to be normal T4 level and T4/T3. |
| |
| group with elevated T4 level or T4/T3 | participants with T4 more than 12.5ug/dl and ratio of T4/T3(T4(ug/dl)/T3 (ng/ml)) > 7.52, which are considered to be elevated T4 level and T4/T3. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| detection of serum selenium | Diagnostic Test | For this case-control study, no intervention will be administered to participants, only serum sample will be collected for selenium assessment |
| Measure | Description | Time Frame |
|---|---|---|
| between-group difference in serum selenium | comparison of the mean serum selenium between the two groups | up to 24 weeks |
| Measure | Description | Time Frame |
|---|---|---|
| between-group difference in serum deiodinase activity | comparison of the mean deiodinase activity between the two groups | up to 24 weeks |
| between-group difference in erythrocyte glutathione peroxidase activity |
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Inclusion Criteria:
Exclusion Criteria:
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Study participants will be recruited from volunteers who undergo health examination in Peking Union Medical College Hospital and meet the inclusion criteria.
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Yanping Liu | Contact | +861069159088 | liuyp1227@vip.sina.com |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Peking Union Medical College Hospital | Recruiting | Beijing | Beijing Municipality | 100730 | China |
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serum
comparison of the mean erythrocyte glutathione peroxidase activity between the two groups
| up to 24 weeks |